HS-72( HS72 )

Catalog No. M12733 CAS No. 1800285-51-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

HS-72
Note

Research use only, not for human use.
Brief Description

HS-72 is an allosteric, selective, cell-permeable inhibitor of inducible Hsp70 (Hsp70i or Hsp72).
Description

HS-72 is an allosteric, selective, cell-permeable inhibitor of inducible Hsp70 (Hsp70i or Hsp72), shows selectivity for Hsp70i over the closely related Hsc70 as well as the broader purinome; inhibits Hsp70i activity in a Huntington’s cell model and across multiple tumorigenic cell lines; causes degradation of HER2 and Akt; is bioavailable in vivo and reduces tumor growth in a spontaneous mouse mammary tumor model; also demonstrates anti-dengue virus activity.
In Vitro

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In Vivo

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Synonyms

HS72
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

HSP
Recptor

HSP
Research Area

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Indication

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CAS Number

1800285-51-1
Formula Weight

364.44
Molecular Formula

C20H24N6O
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

(S)-N-(1-propyl-1H-benzo[d]imidazol-2-yl)-1-(pyrazin-2-yl)piperidine-3-carboxamide

1. Howe MK, et al. Chem Biol. 2014 Dec 18;21(12):1648-59. 2. Howe MK, et al. Antiviral Res. 2016 Jun;130:81-92.

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