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Cipemastat

CAS No. 174265-38-4

Cipemastat( Ro 32-3555 )

Catalog No. M12643 CAS No. 174265-38-4

Cipemastat (Ro 32-3555) is a potent, second-generation, orally active MMP inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Cipemastat
  • Note
    Research use only, not for human use.
  • Brief Description
    Cipemastat (Ro 32-3555) is a potent, second-generation, orally active MMP inhibitor.
  • Description
    Cipemastat (Ro 32-3555) is a potent, second-generation, orally active MMP inhibitor, preferentially inhibits collagenases (MMP-1, -8, and -13) and gelatinase B (MMP-9); inhibits human collagenases 1, 2 and 3 (Ki of 3.0, 4.4 and 3.4 nM), and Ro 323555 is a selective inhibitor of collagenases over the related stromelysin 1, and gelatinases A and B (Ki of 527, 154 and 59 nM); prevents cartilage breakdown both in vitro and in vivo.Rheumatoid Arthritis Phase 3 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Ro 32-3555
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    MMP
  • Recptor
    MMP
  • Research Area
    Inflammation/Immunology
  • Indication
    Rheumatoid Arthritis

Chemical Information

  • CAS Number
    174265-38-4
  • Formula Weight
    436.553
  • Molecular Formula
    C22H36N4O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    1-Piperidinebutanamide, b-(cyclopentylmethyl)-N-hydroxy-g-oxo-a-[(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lewis EJ, et al. Br J Pharmacol. 1997 Jun;121(3):540-6. 2. Whittaker M, et al. Chem Rev. 1999 Sep 8;99(9):2735-76. 3. Liechti FD, et al. Infect Immun. 2014 Apr;82(4):1710-8. 4. Brewster M, et al. Arthritis Rheum. 1998 Sep;41(9):1639-44.
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