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NIK SMI1
CAS No. 1660114-31-7
NIK SMI1( NIK SMI1 | NIKSMI1 | NIK-SMI1 )
Catalog No. M12533 CAS No. 1660114-31-7
NIK SMI1 is a potent, selective small molecule inhibitor of NF-κB inducing kinase (NIK) with Ki of 230±170 pM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 410 | In Stock |
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| 5MG | 174 | In Stock |
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| 10MG | 281 | In Stock |
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| 25MG | 563 | In Stock |
|
| 50MG | 867 | In Stock |
|
| 100MG | 1395 | In Stock |
|
| 200MG | 1907 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNIK SMI1
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NoteResearch use only, not for human use.
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Brief DescriptionNIK SMI1 is a potent, selective small molecule inhibitor of NF-κB inducing kinase (NIK) with Ki of 230±170 pM.
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DescriptionNIK SMI1 is a potent, selective small molecule inhibitor of NF-κB inducing kinase (NIK) with Ki of 230±170 pM; only inhibits 3 out of 222 off-target kinases (KHS1, LRRK2, and PKD1) with >75% inhibition at 1 uM; potently inhibits anti-LTβR-induced nuclear p52 levels in anti-LTβR-stimulated HeLa cells, with no effect on canonical signaling; inhibits BAFF and CD40 signaling, suppresses immune responses in vivo; suppresses disease biomarkers and improves survival and renal function in NZB/W F1 mice.
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In Vitro——
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In Vivo——
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SynonymsNIK SMI1 | NIKSMI1 | NIK-SMI1
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PathwayApoptosis
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TargetNF-κB
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RecptorNF-κB
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Research Area——
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Indication——
Chemical Information
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CAS Number1660114-31-7
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Formula Weight365.389
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Molecular FormulaC20H19N3O4
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Purity>98% (HPLC)
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SolubilityDMSO : 100 mg/mL 273.69 mM
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SMILESO=C(N)C1=NC(C2=CC=CC(C#C[C@@]3(O)C(N(C)CC3)=O)=C2)=CC(OC)=C1
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Chemical Name(R)-6-(3-((3-hydroxy-1-methyl-2-oxopyrrolidin-3-yl)ethynyl)phenyl)-4-methoxypicolinamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Brightbill HD, et al. Nat Commun. 2018 Jan 12;9(1):179.
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