HJC0350

CAS No. 885434-70-8

HJC0350( HJC 0350 | HJC0350 | HJC-0350 )

Catalog No. M19231 CAS No. 885434-70-8

HJC0350 is an effective and specific EPAC2 inhibitor (IC50: 0.3 μM), and no inhibition of Epac1.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 42 In Stock
10MG 58 In Stock
25MG 125 In Stock
50MG 205 In Stock
100MG 354 In Stock
200MG 527 In Stock
500MG 843 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    HJC0350
  • Note
    Research use only, not for human use.
  • Brief Description
    HJC0350 is an effective and specific EPAC2 inhibitor (IC50: 0.3 μM), and no inhibition of Epac1.
  • Description
    HJC 0350 is a selective Epac2 inhibitor (IC50 = 0.3 μM). HJC 0350 displays no effect on Epac1. HJC 0350 blocks stimulation of the Epac2-FL FRET sensor in HEK293 cells.
  • In Vitro
    HJC0350 has an apparent IC50 value of 0.3 μM for competing with 8-NBD-cAMP binding of EPAC2, and is about 133-fold more potent than cAMP. HJC0350 is found not to inhibit EPAC1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP, indicating that it is EPAC2-specific antagonists. Pretreatment of HEK293/EPAC2-FL cells with 10 μM HJC0350 fully blocks the 007-AM induced decrease of FRET.
  • In Vivo
    ——
  • Synonyms
    HJC 0350 | HJC0350 | HJC-0350
  • Pathway
    Apoptosis
  • Target
    NF-κB
  • Recptor
    EPAC2
  • Research Area
    Others-Field
  • Indication
    ——

Chemical Information

  • CAS Number
    885434-70-8
  • Formula Weight
    277.38
  • Molecular Formula
    C15H19NO2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 33.33 mg/mL 120.16 mM
  • SMILES
    Cc1cc(c(c(c1)C)S(=O)(=O)n1cc(cc1C)C)C
  • Chemical Name
    2,4-dimethyl-1-(2,4,6-trimethylphenyl)sulfonylpyrrole

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chen H, et al. J Med Chem. 2013, 56(3), 952-962.
molnova catalog
related products
  • Anti-inflammatory ag...

    Anti-inflammatory agent 51 is an amide/sulfonamide derivative with anti-inflammatory and potentially anti-tumor activity and inhibition of NF-κB activation, which can be used to study acute lung injury and ulcerative colitis.

  • Isoliquiritin apiosi...

    Isoliquiritin apioside isolated from Glycyrrhizae radix rhizome significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB.

  • Narasin (sodium salt...

    Narasin induces tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis by ER stress in glioma cells and inhibits NF-κB signaling by suppressing the phosphorylation of IκBα.