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AP-1/NF-κB activation inhibitor 1
CAS No. 188936-12-1
AP-1/NF-κB activation inhibitor 1( —— )
Catalog No. M37648 CAS No. 188936-12-1
AP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB mediated transcriptional activation (IC50 = 1 μM), without blocking basal transcription driven by the β-actin promoter.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 169 | In Stock |
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| 2MG | 92 | In Stock |
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| 5MG | 155 | In Stock |
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| 10MG | 217 | In Stock |
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| 25MG | 353 | In Stock |
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| 50MG | 514 | In Stock |
|
| 100MG | 714 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1451 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAP-1/NF-κB activation inhibitor 1
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NoteResearch use only, not for human use.
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Brief DescriptionAP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB mediated transcriptional activation (IC50 = 1 μM), without blocking basal transcription driven by the β-actin promoter.
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DescriptionAP-1/NF-κB activation inhibitor 1 is a potent AP-1 and NF-κB mediated transcriptional activation inhibitor (IC50=1 μM), without blocking basal transcription driven by the β-actin promoter. AP-1/NF-κB activation inhibitor 1 has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayApoptosis
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TargetNF-κB
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RecptorNF-κB | DNA/RNA Synthesis
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Research Area——
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Indication——
Chemical Information
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CAS Number188936-12-1
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Formula Weight344.25
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Molecular FormulaC13H11F3N4O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (726.22 mM; Ultrasonic )
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SMILESCCOC(=O)c1cnc(nc1NN1C(=O)C=C(C)C1=O)C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Palanki MS, et al. Novel inhibitors of AP-1 and NF-kappaB mediated gene expression: structure-activity relationship studies of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)++ +pyrimidi ne-5-carboxylate. Bioorg Med Chem Lett. 2000;1?
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