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KZR-504
CAS No. 1629052-78-3
KZR-504( KZR 504 | KZR504 )
Catalog No. M12437 CAS No. 1629052-78-3
KZR-504 (KZR504) is a potent, highly selective inhibitor of immunoproteasome low molecular polypeptide-2 (LMP-2) subunit with IC50 of 51 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 598 | Get Quote |
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| 25MG | 1224 | Get Quote |
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| 50MG | 1971 | Get Quote |
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| 100MG | 2871 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameKZR-504
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NoteResearch use only, not for human use.
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Brief DescriptionKZR-504 (KZR504) is a potent, highly selective inhibitor of immunoproteasome low molecular polypeptide-2 (LMP-2) subunit with IC50 of 51 nM.
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DescriptionKZR-504 (KZR504) is a potent, highly selective inhibitor of immunoproteasome low molecular polypeptide-2 (LMP-2) subunit with IC50 of 51 nM; displays >100-fold selectivity over β1, LMP7, β5, MECL1 and β2 subunits; shows little to no effect on cytokine production in human peripheral blood mononuclear cells (PBMCs) stimulated with LPS, and can be administered at a selective dose in vivo.
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In Vitro——
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In VivoEvaluating the inhibition of LMP2, and antitargets LMP7 and β5, in mouse tissues reveals that KZR-504 (compound 12) is both selective and potent in vivo with >50% target inhibition achieved at >1 mg/kg in all tissues tested except brain.
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SynonymsKZR 504 | KZR504
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PathwayProteasome/Ubiquitin
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TargetProteasome
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RecptorProteasome
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Research Area——
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Indication——
Chemical Information
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CAS Number1629052-78-3
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Formula Weight413.43
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Molecular FormulaC21H23N3O6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 170 mg/mL (411.20 mM)
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SMILESO=C(C1=CC=CC(N1)=O)N[C@@H](CO)C(N[C@@H](CC2=CC=CC=C2)C([C@]3(C)OC3)=O)=O
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Chemical NameN-((S)-3-hydroxy-1-(((S)-1-((S)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)amino)-1-oxopropan-2-yl)-6-oxo-1,6-dihydropyridine-2-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Johnson HWB, et al. ACS Med Chem Lett. 2017 Mar 9;8(4):413-417.
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