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BRD1652
CAS No. 1597438-92-0
BRD1652( BRD 1652 )
Catalog No. M12286 CAS No. 1597438-92-0
BRD1652 is a highly selective, potent, reversible, ATP-competitive GSK3 inhibitor with IC50 of 0.4 nM/4 nM for GSK3α/GSK3β respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameBRD1652
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NoteResearch use only, not for human use.
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Brief DescriptionBRD1652 is a highly selective, potent, reversible, ATP-competitive GSK3 inhibitor with IC50 of 0.4 nM/4 nM for GSK3α/GSK3β respectively.
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DescriptionBRD1652 is a highly selective, potent, reversible, ATP-competitive GSK3 inhibitor with IC50 of 0.4 nM/4 nM for GSK3α/GSK3β respectively; displays >40 fold selectivity over CDKs, ROS and remarkable selectivity versus the kinome; causes a dramatic decrease in autophosphorylation at Tyr279 (pGSK3α) and Tyr216 (pGSK3β) with longer exposure (24h); attenuates amphetamine-induced hyperactivity (AIH) in mice; exhibits superior pharmacokinetic properties.
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In Vitro——
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In Vivo——
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SynonymsBRD 1652
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PathwayPI3K/Akt/mTOR signaling
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TargetGSK-3
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RecptorGSK-3
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Research Area——
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Indication——
Chemical Information
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CAS Number1597438-92-0
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Formula Weight375.395
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Molecular FormulaC20H20F3N3O
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1C2=C(NC3=NNC(C(F)(F)F)=C3[C@]2(C)C4=CC=CC=C4)CC(C)(C)C1
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Chemical Name(S)-4,7,7-Trimethyl-4-phenyl-3-trifluoromethyl-2,4,6,7,8,9-hexahydro-pyrazolo[3,4-b]quinolin-5-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wagner FF, et al. ACS Chem Biol. 2016 Jul 15;11(7):1952-63.
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