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CHIR-98014
CAS No. 252935-94-7
CHIR-98014( CHIR98014 | CHIR 98014 )
Catalog No. M13748 CAS No. 252935-94-7
CHIR-98014 is a potent, selective glycogen synthase kinase 3 (GSK-3) withIC50 of 0.65 and 0.58 nM for GSK-3α and GSK-3β, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 69 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 104 | In Stock |
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| 25MG | 217 | In Stock |
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| 50MG | 346 | In Stock |
|
| 100MG | 555 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1172 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCHIR-98014
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NoteResearch use only, not for human use.
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Brief DescriptionCHIR-98014 is a potent, selective glycogen synthase kinase 3 (GSK-3) withIC50 of 0.65 and 0.58 nM for GSK-3α and GSK-3β, respectively.
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DescriptionCHIR-98014 is a potent, selective glycogen synthase kinase 3 (GSK-3) withIC50 of 0.65 and 0.58 nM for GSK-3α and GSK-3β, respectively; shows less potent activities against 20 other protein kinases including Cdc2 and Erk2; causes GS stimulation in CHO-IR cells and rat hepatocytes, with EC50s of 106 nM and 107 nM, respectively; reduces the viability of ES-CCE cells with IC50 of 1.1 uM, results in a significant activation of the Wnt/beta-catenin pathway in ES-D3 cells combined with CHIR-99021; significantly reduces fasting hyperglycemia within and shows improved glucose disposal in diabetic and insulin-resistant db/db mice.
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In Vitro——
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In Vivo——
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SynonymsCHIR98014 | CHIR 98014
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PathwayPI3K/Akt/mTOR signaling
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TargetGSK-3
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RecptorbFGFR|c-Src|GSK-3α|GSK-3β|p70S6K
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Research Area——
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Indication——
Chemical Information
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CAS Number252935-94-7
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Formula Weight486.3141
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Molecular FormulaC20H17Cl2N9O2
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Purity>98% (HPLC)
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SolubilityDMSO: 11 mg/mL
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SMILESNC1=C(C=CC(NCCNC2=NC=C(N3C=CN=C3)C(=N2)C2=C(Cl)C=C(Cl)C=C2)=N1)[N+]([O-])=O
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Chemical Name2,6-Pyridinediamine, N6-[2-[[4-(2,4-dichlorophenyl)-5-(1H-imidazol-1-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ring DB, et al. Diabetes. 2003 Mar;52(3):588-95.
2. Lian X, et al. Cell Reports. 2015 Jan 13;4(1):170.
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