CHIR-98014( CHIR98014 | CHIR 98014 )

Catalog No. M13748 CAS No. 252935-94-7

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Datasheet

HNMR

HPLC

MSDS

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Product Name

CHIR-98014
Note

Research use only, not for human use.
Brief Description

CHIR-98014 is a potent, selective glycogen synthase kinase 3 (GSK-3) withIC50 of 0.65 and 0.58 nM for GSK-3α and GSK-3β, respectively.
Description

CHIR-98014 is a potent, selective glycogen synthase kinase 3 (GSK-3) withIC50 of 0.65 and 0.58 nM for GSK-3α and GSK-3β, respectively; shows less potent activities against 20 other protein kinases including Cdc2 and Erk2; causes GS stimulation in CHO-IR cells and rat hepatocytes, with EC50s of 106 nM and 107 nM, respectively; reduces the viability of ES-CCE cells with IC50 of 1.1 uM, results in a significant activation of the Wnt/beta-catenin pathway in ES-D3 cells combined with CHIR-99021; significantly reduces fasting hyperglycemia within and shows improved glucose disposal in diabetic and insulin-resistant db/db mice.
In Vitro

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In Vivo

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Synonyms

CHIR98014 | CHIR 98014
Pathway

PI3K/Akt/mTOR signaling
Target

GSK-3
Recptor

bFGFR|c-Src|GSK-3α|GSK-3β|p70S6K
Research Area

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Indication

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CAS Number

252935-94-7
Formula Weight

486.3141
Molecular Formula

C20H17Cl2N9O2
Purity

>98% (HPLC)
Solubility

DMSO: 11 mg/mL
SMILES

NC1=C(C=CC(NCCNC2=NC=C(N3C=CN=C3)C(=N2)C2=C(Cl)C=C(Cl)C=C2)=N1)[N+]([O-])=O
Chemical Name

2,6-Pyridinediamine, N6-[2-[[4-(2,4-dichlorophenyl)-5-(1H-imidazol-1-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-

1. Ring DB, et al. Diabetes. 2003 Mar;52(3):588-95. 2. Lian X, et al. Cell Reports. 2015 Jan 13;4(1):170.

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