STK899704( STK-899704 | STK 899704 )

Catalog No. M12256 CAS No. 1578247-29-6

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Product Name

STK899704
Note

Research use only, not for human use.
Brief Description

A novel tubulin inhibitor that inhibits the proliferation of cancer cell lines with IC50 of 0.2-1.0 uM.
Description

A novel tubulin inhibitor that inhibits the proliferation of cancer cell lines with IC50 of 0.2-1.0 uM; suppresses the growth of HeLa cells with IC50 of 350 nM, prevents the polymerization of purified tubulin in vitro and also depolymerizes microtubule in cultured cells leading to mitotic arrest, associated with increased Cdc25C phosphorylation and the accumulation of both cyclin B1 and Plk1 and apoptosis; shows anticancer activity in vivo.
In Vitro

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In Vivo

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Synonyms

STK-899704 | STK 899704
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Microtubule/Tubulin
Recptor

Microtubule/Tubulin
Research Area

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Indication

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CAS Number

1578247-29-6
Formula Weight

453.498
Molecular Formula

C27H23N3O4
Purity

>98% (HPLC)
Solubility

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SMILES

CCOC(=O)CN1C(=C(C2=CC=CC=C21)C=NNC(=O)C3=CC4=C(O3)C=CC5=CC=CC=C54)C
Chemical Name

Ethyl (E)-2-(2-methyl-3-((2-(naphtho[2,1-b]furan-2-carbonyl)hydrazono)methyl)-1H-indol-1-yl)acetate

1. Sakchaisri K, et al. PLoS One. 2017 Mar 15;12(3):e0173311.

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