Alvimopan

CAS No. 156053-89-3

Alvimopan( ADL 8-2698 | LY 246736 )

Catalog No. M12218 CAS No. 156053-89-3

A selective peripherally acting μ-opioid antagonist with IC50 of 1.7 nM for the treatment of postoperative ileus.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 86 In Stock
2MG 52 In Stock
5MG 85 In Stock
10MG 123 In Stock
25MG 233 In Stock
50MG 368 In Stock
100MG 548 In Stock
200MG 779 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Alvimopan
  • Note
    Research use only, not for human use.
  • Brief Description
    A selective peripherally acting μ-opioid antagonist with IC50 of 1.7 nM for the treatment of postoperative ileus.
  • Description
    A selective peripherally acting μ-opioid antagonist with IC50 of 1.7 nM for the treatment of postoperative ileus; prevents gastrointestinal effects of intravenous morphine without affecting analgesia; orally active.Other Indication Approved(In Vitro):Alvimopan inhibits the loperamide-stimulated [35S]GTPγS binding to membranes containing the cloned human μ-opioid receptor, with an IC50 of 1.7 nM.(In Vivo):Alvimopan (0.1-1.0 mg/kg; p.o.) partially antagonizes the slowing of small intestinal transit of 113Sn-labelled microspheres in rats.Alvimopan (3 mg/kg; p.o.) has no effect on the visceromotor behavioural responses (VMR) induced by noxious colorectal distension (CRD) in conscious rats.
  • In Vitro
    Alvimopan inhibits the loperamide-stimulated [35S]GTPγS binding to membranes containing the cloned human μ-opioid receptor, with an IC50 value of 1.7 nM.
  • In Vivo
    Alvimopan (0.1-1.0 mg/kg; p.o.) partially antagonizes the slowing of small intestinal transit of 113Sn-labelled microspheres produced by morphine in rats.Alvimopan (3 mg/kg; p.o.) has no effect on the visceromotor behavioural responses (VMR) induced by noxious colorectal distension (CRD) in conscious rats.
  • Synonyms
    ADL 8-2698 | LY 246736
  • Pathway
    Endocrinology/Hormones
  • Target
    Opioid Receptor
  • Recptor
    μ-opioidreceptor
  • Research Area
    Other Indications
  • Indication
    Other Disease

Chemical Information

  • CAS Number
    156053-89-3
  • Formula Weight
    424.5326
  • Molecular Formula
    C25H32N2O4
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(O)CNC([C@H](CN1C[C@H](C)[C@](C)(C2=CC=CC(O)=C2)CC1)CC3=CC=CC=C3)=O
  • Chemical Name
    Glycine, N-[(2S)-2-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Fukuda H, et al. Brain Res. 2006 Aug 2;1102(1):63-70. 2. Taguchi A, et al. N Engl J Med. 2001 Sep 27;345(13):935-40. 3. Schmidt WK. Am J Surg. 2001 Nov;182(5A Suppl):27S-38S.
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