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MKT-077

CAS No. 147366-41-4

MKT-077( FJ-776 )

Catalog No. M12027 CAS No. 147366-41-4

MKT-077 (FJ-776) is a highly water-soluble (>200 mg/ml) rhodacyanine dye that exhibits significant antitumor activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 93 In Stock
5MG 81 In Stock
10MG 143 In Stock
25MG 242 In Stock
50MG 380 In Stock
100MG 494 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    MKT-077
  • Note
    Research use only, not for human use.
  • Brief Description
    MKT-077 (FJ-776) is a highly water-soluble (>200 mg/ml) rhodacyanine dye that exhibits significant antitumor activity.
  • Description
    MKT-077 (FJ-776) is a highly water-soluble (>200 mg/ml) rhodacyanine dye that exhibits significant antitumor activity, binds to Hsp70 family member, mortalin (mot-2), and abrogates its interactions with p53; induces release of wild-type p53 from cytoplasmically sequestered p53-mot-2 complexes and rescued its transcriptional activation function; also is a potent telomerase inhibitor with IC50 of 5 uM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    FJ-776
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    HSP
  • Recptor
    HSP70
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    147366-41-4
  • Formula Weight
    432
  • Molecular Formula
    C21H22ClN3OS2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 20 mg/mL; Water: 20 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    O=C1N(CC)/C(S/C1=C2SC3=CC=CC=C3N/2C)=C/C4=CC=CC=[N+]4CC.[Cl-]
  • Chemical Name
    Pyridinium, 1-ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-, chloride (9CI)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Koya K, et al. Cancer Res. 1996 Feb 1;56(3):538-43. 2. Wadhwa R, et al. Cancer Res. 2000 Dec 15;60(24):6818-21. 3. Naasani I, et al. Cancer Res. 1999 Aug 15;59(16):4004-11.
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