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MKT-077
CAS No. 147366-41-4
MKT-077( FJ-776 )
Catalog No. M12027 CAS No. 147366-41-4
MKT-077 (FJ-776) is a highly water-soluble (>200 mg/ml) rhodacyanine dye that exhibits significant antitumor activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
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| 5MG | 81 | In Stock |
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| 10MG | 143 | In Stock |
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| 25MG | 242 | In Stock |
|
| 50MG | 380 | In Stock |
|
| 100MG | 494 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMKT-077
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NoteResearch use only, not for human use.
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Brief DescriptionMKT-077 (FJ-776) is a highly water-soluble (>200 mg/ml) rhodacyanine dye that exhibits significant antitumor activity.
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DescriptionMKT-077 (FJ-776) is a highly water-soluble (>200 mg/ml) rhodacyanine dye that exhibits significant antitumor activity, binds to Hsp70 family member, mortalin (mot-2), and abrogates its interactions with p53; induces release of wild-type p53 from cytoplasmically sequestered p53-mot-2 complexes and rescued its transcriptional activation function; also is a potent telomerase inhibitor with IC50 of 5 uM.
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In Vitro——
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In Vivo——
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SynonymsFJ-776
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetHSP
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RecptorHSP70
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Research Area——
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Indication——
Chemical Information
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CAS Number147366-41-4
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Formula Weight432
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Molecular FormulaC21H22ClN3OS2
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Purity>98% (HPLC)
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SolubilityDMSO: 20 mg/mL; Water: 20 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESO=C1N(CC)/C(S/C1=C2SC3=CC=CC=C3N/2C)=C/C4=CC=CC=[N+]4CC.[Cl-]
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Chemical NamePyridinium, 1-ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-, chloride (9CI)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Koya K, et al. Cancer Res. 1996 Feb 1;56(3):538-43.
2. Wadhwa R, et al. Cancer Res. 2000 Dec 15;60(24):6818-21.
3. Naasani I, et al. Cancer Res. 1999 Aug 15;59(16):4004-11.
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