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SR 48692
CAS No. 146362-70-1
SR 48692( Meclinertant | SR48692 | SR-48692 )
Catalog No. M11989 CAS No. 146362-70-1
A potent, selective and orally active nonpeptide antagonist of the neurotensin receptor with IC50 of 0.99 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 188 | In Stock |
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| 5MG | 409 | In Stock |
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| 10MG | 791 | In Stock |
|
| 25MG | 877 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSR 48692
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective and orally active nonpeptide antagonist of the neurotensin receptor with IC50 of 0.99 nM.
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DescriptionA potent, selective and orally active nonpeptide antagonist of the neurotensin receptor with IC50 of 0.99 nM (guinea pig), without any intrinsic agonist activity; blocks K(+)-evoked release of [3H]dopamine stimulated by neurotensin in guinea pig striatal slices with IC50 of 0.46 nM, competitively antagonizes neurotensin-induced intracellular Ca2+ mobilization with pA2 of 8.13 in H29 cells; reverses the turning behavior induced by intrastriatal injection of neurotensin in mice.Lung Cancer Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsMeclinertant | SR48692 | SR-48692
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PathwayGPCR/G Protein
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TargetNeurotensin Receptor
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RecptorNeurotensin Receptor
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Research AreaCancer
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IndicationLung Cancer
Chemical Information
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CAS Number146362-70-1
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Formula Weight587.073
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Molecular FormulaC32H31ClN4O5
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NC1(C(O)=O)[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C4=NN(C5=CC=NC6=CC(Cl)=CC=C56)C(C7=C(OC)C=CC=C7OC)=C4
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Chemical Name(1r,3r,5r,7r)-2-(1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxamido)adamantane-2-carboxylic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Dubuc I, et al. Br J Pharmacol. 1994 Jun;112(2):352-4.
2. Steinberg R, et al. Neuroscience. 1994 Apr;59(4):921-9.
3. Brouard A, et al. Eur J Pharmacol. 1994 Mar 3;253(3):289-91.
4. Gully D, et al. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):65-9.
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