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Pyrimidyn 7
CAS No. 1440126-94-2
Pyrimidyn 7( Pyrimidyn7 )
Catalog No. M11866 CAS No. 1440126-94-2
Pyrimidyn 7 is a potent, dual-action dynamin GTPase activity inhibitor with IC50 of 1.1 uM/1.8 uM for dynamin I/dynamin II respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePyrimidyn 7
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NoteResearch use only, not for human use.
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Brief DescriptionPyrimidyn 7 is a potent, dual-action dynamin GTPase activity inhibitor with IC50 of 1.1 uM/1.8 uM for dynamin I/dynamin II respectively.
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DescriptionPyrimidyn 7 is a potent, dual-action dynamin GTPase activity inhibitor with IC50 of 1.1 uM/1.8 uM for dynamin I/dynamin II respectively, competitively inhibits both GTP and phospholipid interactions with dynamin; reversibly inhibits CME of both transferrin and EGF in a number of non-neuronal cell lines as well as inhibiting synaptic vesicle endocytosis (SVE) in nerve terminals; blocks clathrin-mediated endocytosis (CME).
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In Vitro——
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In Vivo——
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SynonymsPyrimidyn7
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PathwayCytoskeleton/Cell Adhesion Molecules
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TargetDynamin
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RecptorDynamin
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Research Area——
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Indication——
Chemical Information
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CAS Number1440126-94-2
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Formula Weight363.59
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Molecular FormulaC21H41N5
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Purity>98% (HPLC)
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Solubility——
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SMILESCCCCCCCCCCCCNC1=NC(=NC(=C1)C)NCCN(C)C
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Chemical NameN2-[2-(Dimethylamino)ethyl]-N4-dodecyl-6-methyl-2,4-pyrimidinediamine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. McGeachie AB, et al. ACS Chem Biol. 2013 Jul 19;8(7):1507-18.
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