Pyrimidyn 7( Pyrimidyn7 )

Catalog No. M11866 CAS No. 1440126-94-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

Pyrimidyn 7
Note

Research use only, not for human use.
Brief Description

Pyrimidyn 7 is a potent, dual-action dynamin GTPase activity inhibitor with IC50 of 1.1 uM/1.8 uM for dynamin I/dynamin II respectively.
Description

Pyrimidyn 7 is a potent, dual-action dynamin GTPase activity inhibitor with IC50 of 1.1 uM/1.8 uM for dynamin I/dynamin II respectively, competitively inhibits both GTP and phospholipid interactions with dynamin; reversibly inhibits CME of both transferrin and EGF in a number of non-neuronal cell lines as well as inhibiting synaptic vesicle endocytosis (SVE) in nerve terminals; blocks clathrin-mediated endocytosis (CME).
In Vitro

——
In Vivo

——
Synonyms

Pyrimidyn7
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

Dynamin
Recptor

Dynamin
Research Area

——
Indication

——

CAS Number

1440126-94-2
Formula Weight

363.59
Molecular Formula

C21H41N5
Purity

>98% (HPLC)
Solubility

——
SMILES

CCCCCCCCCCCCNC1=NC(=NC(=C1)C)NCCN(C)C
Chemical Name

N2-[2-(Dimethylamino)ethyl]-N4-dodecyl-6-methyl-2,4-pyrimidinediamine

1. McGeachie AB, et al. ACS Chem Biol. 2013 Jul 19;8(7):1507-18.

Calculator

molnova catalog