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Dynamin IN-2

CAS No. 1345853-49-7

Dynamin IN-2( —— )

Catalog No. M35809 CAS No. 1345853-49-7

Dynamin IN-2 (compound 43) is a Wiskostatin analogue. Dynamin IN-2 is a potent dynamin inhibitor (dynamin I GTPase, IC50= 1.0 μM). Dynamin IN-2 blocks clathrin mediated endocytosis (CME) (IC50= 9.5 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Dynamin IN-2
  • Note
    Research use only, not for human use.
  • Brief Description
    Dynamin IN-2 (compound 43) is a Wiskostatin analogue. Dynamin IN-2 is a potent dynamin inhibitor (dynamin I GTPase, IC50= 1.0 μM). Dynamin IN-2 blocks clathrin mediated endocytosis (CME) (IC50= 9.5 μM).
  • Description
    Dynamin IN-2 (compound 43), a Wiskostatin (HY-12534) analogue, is a potent dynamin inhibitor, with an IC50 of 1.0 μM for dynamin I GTPase. Dynamin IN-2 also blocks clathrin mediated endocytosis (CME), with an IC50 of 9.5 μM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Dynamin
  • Recptor
    Dynamin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1345853-49-7
  • Formula Weight
    364.87
  • Molecular Formula
    C22H21ClN2O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(C(CNCC1=CC=C(Cl)C=C1)O)N2C=3C(C=4C2=CC=CC4)=CC=CC3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Cossar PJ, et al. Wiskostatin and other carbazole scaffolds as off target inhibitors of dynamin I GTPase activity and endocytosis. Eur J Med Chem. 2022 Dec 15;247:115001.?
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