Cart
sales@molnova.com
K02288
CAS No. 1431985-92-0
K02288( K 02288 | K-02288 )
Catalog No. M11838 CAS No. 1431985-92-0
K02288 is a potent, selective inhibitor of BMP signaling.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 30 | In Stock |
|
| 5MG | 47 | In Stock |
|
| 10MG | 80 | In Stock |
|
| 25MG | 149 | In Stock |
|
| 50MG | 260 | In Stock |
|
| 100MG | 385 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameK02288
-
NoteResearch use only, not for human use.
-
Brief DescriptionK02288 is a potent, selective inhibitor of BMP signaling.
-
DescriptionK02288 is a potent, selective inhibitor of BMP signaling with IC50 of 1.8/1.1/34.4/6.3 nM for ALK/1/2/3/6, displays 300-fold selectivity for ALK2 over the TGF-β receptor ALK5 and ALK4; also wekaly inhibits type II BMP receptor ActRIIA (IC50=220 nM); specifically inhibits the BMP-induced Smad pathway without affecting TGF-β signaling and induces dorsalization of zebrafish embryos; inhibits BMP9-induced phosphorylation of SMAD1/5/8 in HUVECs to reduce both the SMAD and the Notch-dependent transcriptional responses, inhibits functional angiogenesis.
-
In Vitro——
-
In Vivo——
-
SynonymsK 02288 | K-02288
-
PathwayTGF-beta/Smad
-
TargetTGFBR
-
RecptorALK1|ALK2|ALK3|ALK4|ALK6
-
Research AreaOther Indications
-
Indication——
Chemical Information
-
CAS Number1431985-92-0
-
Formula Weight352.3838
-
Molecular FormulaC20H20N2O4
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 58.6 mg/mL
-
SMILESOC1=CC=CC(C2=CC(C3=CC(OC)=C(OC)C(OC)=C3)=C(N)N=C2)=C1
-
Chemical NamePhenol, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Sanvitale CE, et al. PLoS One. 2013 Apr 30;8(4):e62721.
2. Mohedas AH, et al. J Med Chem. 2014 Oct 9;57(19):7900-15.
3. Kerr G, et al. Angiogenesis. 2015 Apr;18(2):209-17.
4. Windhausen T, et al. Molecules. 2015 Apr 24;20(5):7586-601.
molnova catalog
related products
-
IN-1130
A potent ALK5 inhibitor; inhibits the purified kinase domain of ALK5-mediated Smad3 phosphorylation with an IC50 of 5.3 nM.
-
Kartogenin
Kartogenin is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.
-
BMP signaling agonis...
BMP signaling agonist sb4 is a small molecule BMP signaling agonist with EC50 of 73.6 nM.
