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K02288
CAS No. 1431985-92-0
K02288( K 02288 | K-02288 )
Catalog No. M11838 CAS No. 1431985-92-0
K02288 is a potent, selective inhibitor of BMP signaling.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 55 | In Stock |
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| 2MG | 31 | In Stock |
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| 5MG | 49 | In Stock |
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| 10MG | 85 | In Stock |
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| 25MG | 157 | In Stock |
|
| 50MG | 269 | In Stock |
|
| 100MG | 398 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameK02288
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NoteResearch use only, not for human use.
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Brief DescriptionK02288 is a potent, selective inhibitor of BMP signaling.
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DescriptionK02288 is a potent, selective inhibitor of BMP signaling with IC50 of 1.8/1.1/34.4/6.3 nM for ALK/1/2/3/6, displays 300-fold selectivity for ALK2 over the TGF-β receptor ALK5 and ALK4; also wekaly inhibits type II BMP receptor ActRIIA (IC50=220 nM); specifically inhibits the BMP-induced Smad pathway without affecting TGF-β signaling and induces dorsalization of zebrafish embryos; inhibits BMP9-induced phosphorylation of SMAD1/5/8 in HUVECs to reduce both the SMAD and the Notch-dependent transcriptional responses, inhibits functional angiogenesis.
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In Vitro——
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In Vivo——
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SynonymsK 02288 | K-02288
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PathwayTGF-beta/Smad
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TargetTGFBR
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RecptorALK1|ALK2|ALK3|ALK4|ALK6
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Research AreaOther Indications
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Indication——
Chemical Information
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CAS Number1431985-92-0
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Formula Weight352.3838
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Molecular FormulaC20H20N2O4
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 58.6 mg/mL
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SMILESOC1=CC=CC(C2=CC(C3=CC(OC)=C(OC)C(OC)=C3)=C(N)N=C2)=C1
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Chemical NamePhenol, 3-[6-amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sanvitale CE, et al. PLoS One. 2013 Apr 30;8(4):e62721.
2. Mohedas AH, et al. J Med Chem. 2014 Oct 9;57(19):7900-15.
3. Kerr G, et al. Angiogenesis. 2015 Apr;18(2):209-17.
4. Windhausen T, et al. Molecules. 2015 Apr 24;20(5):7586-601.
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