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Home - Products - Cytoskeleton/Cell Adhesion Molecules - Microtubule/Tubulin - DZ-2384

DZ-2384

CAS No. 1403850-91-8

DZ-2384( DZ2384 )

Catalog No. M11690 CAS No. 1403850-91-8

DZ-2384 (DZ2384) is a microtubule-targeting agent, exhibits potent antitumor activity in models of multiple cancer types.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DZ-2384
  • Note
    Research use only, not for human use.
  • Brief Description
    DZ-2384 (DZ2384) is a microtubule-targeting agent, exhibits potent antitumor activity in models of multiple cancer types.
  • Description
    DZ-2384 (DZ2384) is a microtubule-targeting agent, exhibits potent antitumor activity in models of multiple cancer types; binds the vinca domain of tubulin, DZ-2384 has potent antitumor activity as a single agent and in combination with gemcitabine both in vitro and in vivo, enhances gemcitabine activity in mouse models of pancreatic cancer.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    DZ2384
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Microtubule/Tubulin
  • Recptor
    Microtubule/Tubulin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1403850-91-8
  • Formula Weight
    645.677
  • Molecular Formula
    C34H36FN5O7
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(C)C(C(=O)NC1CC2=CC3=C(C=C2)OC4C3(C5=C(N4)C=CC(=C5)F)C6=C(N=C(O6)C(NC1=O)C(C)(C)C)C7=NC(=CO7)CO)O
  • Chemical Name
    (S)-N-((15aR,110bS,3S,6S)-3-(tert-butyl)-19-fluoro-24-(4-(hydroxymethyl)oxazol-2-yl)-5-oxo-15a,110b-dihydro-16H-4-aza-1(10b,2)-benzofuro[2,3-b]indola-2(5,2)-oxazolacycloheptaphane-6-yl)-2-hydroxy-3-methylbutanamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ding H, et al. Angew Chem Int Ed Engl. 2015 Apr 13;54(16):4818-22. 2. Wieczorek M, et al. Sci Transl Med. 2016 Nov 16;8(365):365ra159. 3. Bernier C, et al. Anticancer Drugs. 2018 Jun 22. doi: 10.1097/CAD.0000000000000653.
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