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USP7i-1

CAS No. 1381291-36-6

USP7i-1( USP7 inhibitor 1 )

Catalog No. M11579 CAS No. 1381291-36-6

USP7i-1 is a potent, selective USP7 inhibitor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    USP7i-1
  • Note
    Research use only, not for human use.
  • Brief Description
    USP7i-1 is a potent, selective USP7 inhibitor.
  • Description
    USP7i-1 is a potent, selective USP7 inhibitor.
  • In Vitro
    USP7-IN-1 (Example 2) is a selective and reversible inhibitor of USP7, with an IC50 of 77 μM, and shows no inhibition of USP8, USP5, Uch-L1, Uch-L3 or caspase 3. USP7-IN-1 inhibits the proliferation of HCT116 cells, with a GI50 of 67 μM.
  • In Vivo
    ——
  • Synonyms
    USP7 inhibitor 1
  • Pathway
    Proteasome/Ubiquitin
  • Target
    DUB
  • Recptor
    DUB
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1381291-36-6
  • Formula Weight
    425.913
  • Molecular Formula
    C23H24ClN3O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 40 mg/mL 93.92 mM
  • SMILES
    C1CN(CCC1(CN2C=NC3=C(C2=O)C=CC(=C3)Cl)O)C(=O)CCC4=CC=CC=C4
  • Chemical Name
    7-chloro-3-((4-hydroxy-1-(3-phenylpropanoyl)piperidin-4-yl)methyl)quinazolin-4(3H)-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Weisberg EL, et al. Nat Chem Biol. 2017 Dec;13(12):1207-1215. 2. Kessler BM. Expert Opin Ther Pat. 2014 May;24(5):597-602.
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