EZH2-IN-3( EZH2-IN-3 | EZH2 inhibitor 3 | EZH2-inhibitor-3 )

Catalog No. M11560 CAS No. 1377997-28-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

EZH2-IN-3
Note

Research use only, not for human use.
Brief Description

EZH2-IN-3 is a highly selective small molecule inhibitor of EZH2 and EZH1.
Description

EZH2-IN-3 is a highly selective small molecule inhibitor of EZH2 and EZH1 with IC50 of 21/197/213 nM for wt EZH2/EZH2 Y641N/wt EZH1 respectively; suppresses global histone H3-lysine 27 methylation and cause selective proliferation defects.
In Vitro

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In Vivo

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Synonyms

EZH2-IN-3 | EZH2 inhibitor 3 | EZH2-inhibitor-3
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

HMTase
Research Area

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Indication

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CAS Number

1377997-28-8
Formula Weight

490.004
Molecular Formula

C27H28ClN5O2
Purity

>98% (HPLC)
Solubility

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SMILES

O=C(NC1CC(C)(C)NC(C)(C)C1)C2=CC=C(OC3=CC=CC(C4=CC=NN=C4)=C3C#N)C(Cl)=C2
Chemical Name

3-chloro-4-(2-cyano-3-(pyridazin-4-yl)phenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide

1. Garapaty-Rao S, et al. Chem Biol. 2013 Nov 21;20(11):1329-39.

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