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BRD 0476
CAS No. 1314958-91-2
BRD 0476( ML187 )
Catalog No. M11273 CAS No. 1314958-91-2
BRD 0476 (ML187) is a selective, moderate inhibitor of ubiquitin-specific peptidase 9X (USP9X).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 873 | Get Quote |
|
| 50MG | 1782 | Get Quote |
|
| 100MG | 2250 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameBRD 0476
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NoteResearch use only, not for human use.
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Brief DescriptionBRD 0476 (ML187) is a selective, moderate inhibitor of ubiquitin-specific peptidase 9X (USP9X).
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DescriptionBRD 0476 (ML187) is a selective, moderate inhibitor of ubiquitin-specific peptidase 9X (USP9X), inhibits pancreatic β-cell apoptosis that inhibits IFN-γ-induced JAK2 and STAT1 signaling to promote β-cell survival; does not has kinase inhibitory activity, and no effect no effect on JAK1, JAK2, or JAK3 activities, and the deubiquitinase ubiquitin-specific peptidase 9X (USP9X) is an intracellular target of BRD0476.
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In Vitro——
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In Vivo——
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SynonymsML187
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PathwayProteasome/Ubiquitin
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TargetDUB
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RecptorDUB
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Research Area——
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Indication——
Chemical Information
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CAS Number1314958-91-2
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Formula Weight674.769
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Molecular FormulaC35H38N4O8S
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NC1=C2C=CC=CC2=CC=C1)NC3=C(O[C@@H](CN(S(=O)(C4=CC=C(OCCO5)C5=C4)=O)C)[C@H](C)CN([C@@H](C)CO)C6=O)C6=CC=C3
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Chemical NameN-(((2R,3R)-5-((S)-1-hydroxypropan-2-yl)-3-methyl-10-(3-(naphthalen-1-yl)ureido)-6-oxo-3,4,5,6-tetrahydro-2H-benzo[b][1,5]oxazocin-2-yl)methyl)-N-methyl-2,3-dihydrobenzo[b][1,4]dioxine-6-sulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chou DH, et al. J Am Chem Soc. 2015 Jun 24;137(24):7929-34.
2. Faloon PW, et al. Probe Reports from the NIH Molecular Libraries Program [Internet].
3. Chou DH, et al. ACS Med Chem Lett. 2011 Sep 8;2(9):698-702.
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