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Home - Products - Angiogenesis - JAK - PF-956980

PF-956980

CAS No. 1262832-74-5

PF-956980( PF 956980 | PF956980 )

Catalog No. M11099 CAS No. 1262832-74-5

A potent, highly specific JAK3 inhibitor with IC50 of 4 nM; shows only modest inhibition of PKA (6.7 uM) and LCK (10.9 uM) in vitro.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    PF-956980
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, highly specific JAK3 inhibitor with IC50 of 4 nM; shows only modest inhibition of PKA (6.7 uM) and LCK (10.9 uM) in vitro.
  • Description
    A potent, highly specific JAK3 inhibitor with IC50 of 4 nM; shows only modest inhibition of PKA (6.7 uM) and LCK (10.9 uM) in vitro; selectively downregulates JAK2 and JAK3 mRNA, corresponding to changes observed at the protein level; shows in vivo activity consistent with in vitro enzyme and whole blood assays (39 ng/ml); dose-dependently inhibits the DTH response in mice with EC50 of 5 mg/kg.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PF 956980 | PF956980
  • Pathway
    Angiogenesis
  • Target
    JAK
  • Recptor
    JAK
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    1262832-74-5
  • Formula Weight
    342.44
  • Molecular Formula
    C18H26N6O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(N1C[C@H](N(C)C2=C3C(NC=C3)=NC=N2)[C@H](C)CC1)N4CCCC4
  • Chemical Name
    {(3R,4R)-4-Methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl}-pyrrolidin-1-yl-methanone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Changelian PS, et al. Blood. 2008 Feb 15;111(4):2155-7. 2. Steele AJ, et al. Blood. 2010 Nov 25;116(22):4569-77. 3. Field SD, et al. ACS Chem Biol. 2017 May 19;12(5):1183-1187.
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