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SAK3
CAS No. 1256269-87-0
SAK3( T-VGCC enhancer SAK3 )
Catalog No. M11047 CAS No. 1256269-87-0
SAK3 (T-VGCC enhancer SAK3) is a potent, orally acitve enhancer of T-type voltage-gated Ca2+ channel (T-VGCC).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 274 | In Stock |
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| 10MG | 414 | In Stock |
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| 25MG | 658 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSAK3
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NoteResearch use only, not for human use.
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Brief DescriptionSAK3 (T-VGCC enhancer SAK3) is a potent, orally acitve enhancer of T-type voltage-gated Ca2+ channel (T-VGCC).
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DescriptionSAK3 (T-VGCC enhancer SAK3) is a potent, orally acitve enhancer of T-type voltage-gated Ca2+ channel (T-VGCC), enhances CaV3.1 and CaV3.3, but not CaV3.2 activity at concentrations of 0.01-10 nM in neuro2A cells in vitro; significantly enhanced acetylcholine (ACh) release in the hippocampal CA1 region of na ve mice (0.5 mg/kg, p.o.); significantly enhanced hippocampal ACh levels in olfactory-bulbectomized (OBX) mice, rescuing impaired memory-related behaviors.
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In VitroSAK3 (0.01-10 nM) significantly enhances Cav3.1 or Cav3.3 currents in neuro2A cells ectopically expressing Cav3.1 or Cav3.3, respectively. Cell Viability AssayCell Line:Cav3.1 or Cav3.3-overexpressing neuro2A cells Concentration:0.1 nM Incubation Time:270 sResult:Rapidly increased Ca2+ currents
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In VivoAcute SAK3 (0.5 mg/kg) oral administration promotes acetylcholine (ACh) release in hippocampal CA1 via T-VGCC stimulation via enhancing T-type Ca2+ channel. Animal Model:Animal Model:Cav3.1 knockout (KO) miceDosage: 0.5 mg/kg Administration:Administered p.o.Result:Significantly increased ACh release in CA1, peaking at 20 min after oral administration.
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SynonymsT-VGCC enhancer SAK3
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PathwayGPCR/G Protein
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TargetCalcium Channel
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RecptorCalcium Channel
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Research Area——
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Indication——
Chemical Information
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CAS Number1256269-87-0
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Formula Weight369.421
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Molecular FormulaC20H23N3O4
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(C1=C(N2CCCCC2)C3(N4C=CC=C(C)C4=NC3=O)CC1=O)OCC
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Chemical NameEthyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yabuki Y, et al. Neuropharmacology. 2017 May 1;117:1-13.
2. Izumi H, et al. Neuroscience. 2018 May 1;377:87-97.
3. Husain N, et al. Pharmacology. 2018;101(5-6):309-321.
4. Wang S, et al. PLoS One. 2018 Dec 20;13(12):e0206986.
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