SAK3

Research use only, not for human use.

SAK3 (T-VGCC enhancer SAK3) is a potent, orally acitve enhancer of T-type voltage-gated Ca2+ channel (T-VGCC).

SAK3 (T-VGCC enhancer SAK3) is a potent, orally acitve enhancer of T-type voltage-gated Ca2+ channel (T-VGCC), enhances CaV3.1 and CaV3.3, but not CaV3.2 activity at concentrations of 0.01-10 nM in neuro2A cells in vitro; significantly enhanced acetylcholine (ACh) release in the hippocampal CA1 region of na ve mice (0.5 mg/kg, p.o.); significantly enhanced hippocampal ACh levels in olfactory-bulbectomized (OBX) mice, rescuing impaired memory-related behaviors.

SAK3 (0.01-10 nM) significantly enhances Cav3.1 or Cav3.3 currents in neuro2A cells ectopically expressing Cav3.1 or Cav3.3, respectively. Cell Viability AssayCell Line:Cav3.1 or Cav3.3-overexpressing neuro2A cells Concentration:0.1 nM Incubation Time:270 sResult:Rapidly increased Ca2+ currents

Acute SAK3 (0.5 mg/kg) oral administration promotes acetylcholine (ACh) release in hippocampal CA1 via T-VGCC stimulation via enhancing T-type Ca2+ channel. Animal Model:Animal Model:Cav3.1 knockout (KO) miceDosage: 0.5 mg/kg Administration:Administered p.o.Result:Significantly increased ACh release in CA1, peaking at 20 min after oral administration.

T-VGCC enhancer SAK3

GPCR/G Protein

Calcium Channel

Calcium Channel

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1256269-87-0

369.421

C20H23N3O4

>98% (HPLC)

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O=C(C1=C(N2CCCCC2)C3(N4C=CC=C(C)C4=NC3=O)CC1=O)OCC

Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate

(-20℃)

With Ice Pack

≥ 2 years