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Home - Products - GPCR/G Protein - Calcium Channel - Z-944

Z-944

CAS No. 1199236-64-0

Z-944( Z944 )

Catalog No. M10714 CAS No. 1199236-64-0

Z-944 is a potent, highly selective and oral T-type calcium channel blocker with IC50 of 50-160 nM for human Cav3.1, Cav3.2, and Cav3.3 channels.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Z-944
  • Note
    Research use only, not for human use.
  • Brief Description
    Z-944 is a potent, highly selective and oral T-type calcium channel blocker with IC50 of 50-160 nM for human Cav3.1, Cav3.2, and Cav3.3 channels.
  • Description
    Z-944 is a potent, highly selective and oral T-type calcium channel blocker with IC50 of 50-160 nM for human Cav3.1, Cav3.2, and Cav3.3 channels; displays 70 times more potent for T-type blockade than for blockade of the N-type channel (IC50=11 uM); potently suppress seizure activity and attenuates burst firing of thalamic reticular nucleus neurons in the GAERS model of absence epilepsy; restores cortical synchrony and thalamocortical connectivity in a rat model of neuropathic pain.Pain Phase 1 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Z944
  • Pathway
    GPCR/G Protein
  • Target
    Calcium Channel
  • Recptor
    Calcium Channel
  • Research Area
    Neurological Disease
  • Indication
    Pain

Chemical Information

  • CAS Number
    1199236-64-0
  • Formula Weight
    383.89
  • Molecular Formula
    C19H27ClFN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (130.25 mM)
  • SMILES
    O=C(NCC1CCN(CC(NC(C)(C)C)=O)CC1)C2=CC(F)=CC(Cl)=C2
  • Chemical Name
    N-[[1-[2-(tert-butylamino)-2-oxoethyl]piperidin-4-yl]methyl]-3-chloro-5-fluorobenzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tringham E, et al. Sci Transl Med. 2012 Feb 15;4(121):121ra19. 2. Casillas-Espinosa PM, et al. PLoS One. 2015 Aug 14;10(8):e0130012. 3. LeBlanc BW, et al. Pain. 2016 Jan;157(1):255-63.
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