AC-265347

Research use only, not for human use.

AC-265347 is a calcimimetic acting agent and highly efficacious, orally active allosteric agonist (PAM) of CaSR with IC50 of 10 nM in PI hydrolysis assays.

AC-265347 is a calcimimetic acting agent and highly efficacious, orally active allosteric agonist (PAM) of CaSR with IC50 of 10 nM in PI hydrolysis assays; activates CaSR signaling in cellular proliferation with IC50 of 30 nM; significantly stimulates greater responses than Cinacalcet or Calindol at each of four loss-of-function human polymorphic CaSR variants, and does not inhibit the CYP2D6 cytochrome P450 isozyme; reduced serum parathyroid hormone (PTH) in rats, also reduces plasma ionizable calcium ([Ca(2+)](o)).

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AC265347

GPCR/G Protein

CaSR

CaSR

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1253901-26-6

283.39

C17H17NOS

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (352.87 mM)

CC(C1=NC2=CC=CC=C2S1)(O)C3=CC=C(C)C=C3C

1-(1,3-benzothiazol-2-yl)-1-(2,4-dimethylphenyl)ethanol

(-20℃)

With Ice Pack

≥ 2 years