APY0201( APY0201 | APY-0201 | APY 0201 )

Catalog No. M10917 CAS No. 1232221-74-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

APY0201
Note

Research use only, not for human use.
Brief Description

APY0201 is a potent, highly selective, ATP-competitive PIKfyve inhibitor (IC50=5.2 nM) that interrupts the conversion of phosphatidylinositol 3-phosphate (PtdIns3P) to PtdIns(3,5)P2.
Description

APY0201 is a potent, highly selective, ATP-competitive PIKfyve inhibitor (IC50=5.2 nM) that interrupts the conversion of phosphatidylinositol 3-phosphate (PtdIns3P) to PtdIns(3,5)P2; a unique small molecular IL-12/23 production inhibitor.
In Vitro

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In Vivo

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Synonyms

APY0201 | APY-0201 | APY 0201
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PIKfyve
Research Area

Inflammation/Immunology
Indication

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CAS Number

1232221-74-7
Formula Weight

413.48
Molecular Formula

C23H23N7O
Purity

>98% (HPLC)
Solubility

DMSO: 10 mM
SMILES

CC1=CC(/C=N/NC2=NC3=CC(C4=CC=NC=C4)=NN3C(N5CCOCC5)=C2)=CC=C1
Chemical Name

(E)-4-(5-(2-(3-methylbenzylidene)hydrazinyl)-2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)morpholine

1.Hayakawa N, et al. Bioorg Med Chem. 2014 Jun 1;22(11):3021-9.

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