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LAS195319
CAS No. 1605328-04-8
LAS195319( LAS-195319 | LAS 195319 )
Catalog No. M12307 CAS No. 1605328-04-8
LAS195319 (LAS-195319) is a potent, selective, inhaled PI3Kδ inhibitor with IC50 of 0.5 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1503 | Get Quote |
|
| 50MG | 3042 | Get Quote |
|
| 100MG | 4140 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameLAS195319
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NoteResearch use only, not for human use.
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Brief DescriptionLAS195319 (LAS-195319) is a potent, selective, inhaled PI3Kδ inhibitor with IC50 of 0.5 nM.
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DescriptionLAS195319 (LAS-195319) is a potent, selective, inhaled PI3Kδ inhibitor with IC50 of 0.5 nM, weakly inhibits PI3Kβ and γ (>20-fold), no activity against PI3Kα; inhibits M-CSF induced pAkt (Thr308) in THP-1 cells with IC50 of 2.7 nM; inhibits inflammatory cell infiltration induced by OVA challenge in a Brown Norway rat model.
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In Vitro——
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In Vivo——
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SynonymsLAS-195319 | LAS 195319
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorPI3K
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Research Area——
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Indication——
Chemical Information
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CAS Number1605328-04-8
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Formula Weight594.654
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Molecular FormulaC29H26N10O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=C2C(=O)N(C(=NN2C=C1)C(C)NC3=NC=NC4=C3C(=CN4)C5=C6C=CNC6=CC(=C5)NS(=O)(=O)N)C7=CC=CC=C7
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Chemical NameN-[4-(4-{[(1S)-1-(5-Methyl-4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-1H-indol-6-yl]sulfamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Erra M, et al. J Med Chem. 2018 Oct 29. doi: 10.1021/acs.jmedchem.8b00873.
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