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NIBR-17

CAS No. 944396-88-7

NIBR-17( —— )

Catalog No. M27568 CAS No. 944396-88-7

NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 263 In Stock
5MG 223 In Stock
10MG 332 In Stock
25MG 532 In Stock
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Biological Information

  • Product Name
    NIBR-17
  • Note
    Research use only, not for human use.
  • Brief Description
    NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.
  • Description
    NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    PI3K
  • Recptor
    DEPTOR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    944396-88-7
  • Formula Weight
    380.4
  • Molecular Formula
    C18H20N8O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COc(cc1)ncc1Nc1cc(-c2cnc(N)nc2)nc(N2CCOCC2)n1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hou Y, et al. Design, Synthesis, and Biological Evaluation of Icaritin Derivatives as Novel Putative DEPTOR Inhibitors for Multiple Myeloma Treatment. J Med Chem. 2021 Oct 28;64(20):14942-14954.
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