ML132( NCGC-00183434 | CID-4462093 )

Catalog No. M10910 CAS No. 1230628-71-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ML132
Note

Research use only, not for human use.
Brief Description

ML132 (NCGC-00183434, CID-4462093) is a highly potent, selective Caspase 1 inhibitor with IC50 of 0.023 nM.
Description

ML132 (NCGC-00183434, CID-4462093) is a highly potent, selective Caspase 1 inhibitor with IC50 of 0.023 nM, displays >1,000-fold selectivity over a panel of 9 caspases.
In Vitro

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In Vivo

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Synonyms

NCGC-00183434 | CID-4462093
Pathway

Apoptosis
Target

Caspase
Recptor

Caspase
Research Area

Cancer
Indication

——

CAS Number

1230628-71-3
Formula Weight

477.941
Molecular Formula

C22H28ClN5O5
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (523.08 mM)
SMILES

O=C(O)C[C@H](NC([C@H]1N(C([C@@H](NC(C2=CC=C(N)C(Cl)=C2)=O)C(C)(C)C)=O)CCC1)=O)C#N
Chemical Name

(S)-3-((S)-1-((S)-2-(4-amino-3-chlorobenzamido)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-3-cyanopropanoic acid

1. Boxer MB, et al. A small molecule inhibitor of Caspase 1. Probe Reports from the NIH Molecular Libraries Program [Internet].

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