MLT-747( MLT747 | MLT 747 )

Catalog No. M13311 CAS No. 2097853-86-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

MLT-747
Note

Research use only, not for human use.
Brief Description

MLT-747 (MLT747) is a potent, selective, allosteric inhibitor of MALT1 paracaspase with IC50 of 14 nM; binds MALT1 in the allosteric Trp580 pocket.
Description

MLT-747 (MLT747) is a potent, selective, allosteric inhibitor of MALT1 paracaspase with IC50 of 14 nM; binds MALT1 in the allosteric Trp580 pocket, reversibly binds and stabilizes human mutant MALT1-W580S in vitro and in MALT1mut/mut B cells, inhibits MALT1 peptide cleavage.
In Vitro

MLT-747 (0-20 μM) stabilizes cellular MALT1-W580S with an EC50 of 314 nM.
In Vivo

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Synonyms

MLT747 | MLT 747
Pathway

Apoptosis
Target

Caspase
Recptor

Caspase
Research Area

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Indication

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CAS Number

2097853-86-4
Formula Weight

478.334
Molecular Formula

C20H21Cl2N7O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (209.06 mM)
SMILES

O=C(NC1=CC(Cl)=C(C(N2CCCC2)=O)N=C1)NC3=C([C@@H](OC)C)N4C(N=C3)=CC(Cl)=N4
Chemical Name

(S)-1-(5-chloro-6-(pyrrolidine-1-carbonyl)pyridin-3-yl)-3-(2-chloro-7-(1-methoxyethyl)pyrazolo[1,5-a]pyrimidin-6-yl)urea

1. Quancard J, et al. Nat Chem Biol. 2019 Jan 28. doi: 10.1038/s41589-018-0222-1.

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