Mirin( Mirin )

Catalog No. M10709 CAS No. 1198097-97-0

A small molecule inhibitor of MRN (Mre11-Rad50-Nbs1) pathway that inhibits Mre11-associated exonuclease activity.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	48	In Stock
5MG	48	In Stock
10MG	75	In Stock
25MG	136	In Stock
50MG	221	In Stock
100MG	407	In Stock
200MG	531	In Stock
500MG	853	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

Mirin
Note

Research use only, not for human use.
Brief Description

A small molecule inhibitor of MRN (Mre11-Rad50-Nbs1) pathway that inhibits Mre11-associated exonuclease activity.
Description

A small molecule inhibitor of MRN (Mre11-Rad50-Nbs1) pathway that inhibits Mre11-associated exonuclease activity; prevents MRN-dependent activation of ATM (IC50=12 uM) without affecting ATM protein kinase activity; inhibits Mre11 nuclease activity at 100 uM, does not inhibit ExoIII nuclease activity; inhibits the G2 checkpoint, and blocks homology-directed repair (HDR) in mammalian cells.
In Vitro

——
In Vivo

——
Synonyms

Mirin
Pathway

Others
Target

Other Targets
Recptor

MRN
Research Area

Cancer
Indication

——

Chemical Information

CAS Number

1198097-97-0
Formula Weight

220.2477
Molecular Formula

C10H8N2O2S
Purity

>98% (HPLC)
Solubility

DMSO: ≥ 31 mg/mL
SMILES

O=C1NC(S/C1=C\C2=CC=C(O)C=C2)=N
Chemical Name

4(5H)-Thiazolone, 2-amino-5-[(4-hydroxyphenyl)methylene]-, (5Z)-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Dupré A, et al. Nat Chem Biol. 2008 Feb;4(2):119-25. 2. Lee JH, et al. J Biol Chem. 2013 May 3;288(18):12840-51. 3. Rozier L, et al. Mol Cell. 2013 Mar 28;49(6):1097-107.

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