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SOD1-Derlin-1 inhibitor 56-59

CAS No. 2170170-27-9

SOD1-Derlin-1 inhibitor 56-59( —— )

Catalog No. M35329 CAS No. 2170170-27-9

SOD1-Derlin-1 inhibitor 56-59 is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor 56-59 is potential in Amyotrophic lateral sclerosis (ALS) research.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 44 In Stock
5MG 40 In Stock
10MG 61 In Stock
25MG 126 In Stock
50MG 182 In Stock
100MG 274 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    SOD1-Derlin-1 inhibitor 56-59
  • Note
    Research use only, not for human use.
  • Brief Description
    SOD1-Derlin-1 inhibitor 56-59 is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor 56-59 is potential in Amyotrophic lateral sclerosis (ALS) research.
  • Description
    SOD1-Derlin-1 inhibitor-2 (compound 56-59) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-2 attenuates the interactions between Derlin-1 and SOD1mut. SOD1-Derlin-1 inhibitor-2 can be used for the research of amyotrophic lateral sclerosis (ALS).
  • In Vitro
    ——
  • In Vivo
    Animal Model:ALS model C57BL/6 mice Dosage:3?mM, flow rate 0.15?μL/h Administration:intracerebroventrical injection Result:Had significantly delayed onset, by a median of 4.5 weeks (14.5% improvement) and prolonged survival, by a median of 5 weeks (14.2% improvement).
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2170170-27-9
  • Formula Weight
    386.47
  • Molecular Formula
    C22H18N4OS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (129.38 mM; Ultrasonic (<60°C)
  • SMILES
    Nc1c(sc2nc(ccc12)-c1cccnc1)C(=O)N(CC=C)c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tsuburaya N, et al. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model. Nat Commun. 2018 Jul 10;9(1):2668.?
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