Aurora A-IN-10( TC-S 7010 | TC S 7010 | TCS7010 )

Catalog No. M10550 CAS No. 1158838-45-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Aurora A-IN-10
Note

Research use only, not for human use.
Brief Description

A potent, highly selective Aurora A inhibitor with IC50 of 3.4 nM; displays >1,000-fold selectivity over Aurora B (IC50=3.4 uM) or CDKs.
Description

A potent, highly selective Aurora A inhibitor with IC50 of 3.4 nM; displays >1,000-fold selectivity over Aurora B (IC50=3.4 uM) or CDKs; A useful tool compound for investigating the cellular role of Aurora A kinases without the complication of also inhibiting Aurora B.
In Vitro

TCS7010 is exceptionally selective Aurora A inhibitors. TCS7010 is an useful tool compounds for investigating the cellular role of Aurora A kinases without the complication of also inhibiting Aurora B.
In Vivo

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Synonyms

TC-S 7010 | TC S 7010 | TCS7010
Pathway

Cell Cycle/DNA Damage
Target

Aurora Kinase
Recptor

Aurora A| Aurora B| Aurora C
Research Area

Cancer
Indication

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CAS Number

1158838-45-9
Formula Weight

588.075
Molecular Formula

C31H31ClFN7O2
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C(NC1=CC=CC=C1Cl)C2=CC=C(NC3=NC(NC4=CC=C(CC(N5CCN(CC)CC5)=O)C=C4)=NC=C3F)C=C2
Chemical Name

Benzamide, N-(2-chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-

1. Aliagas-Martin I, et al. J Med Chem. 2009 May 28;52(10):3300-7.

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