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KY02111
CAS No. 1118807-13-8
KY02111( KY02111 | KY 02111 | KY-02111 )
Catalog No. M10427 CAS No. 1118807-13-8
KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 32 | In Stock |
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| 10MG | 53 | In Stock |
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| 25MG | 116 | In Stock |
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| 50MG | 215 | In Stock |
|
| 100MG | 323 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameKY02111
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NoteResearch use only, not for human use.
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Brief DescriptionKY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling.
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DescriptionKY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, may act downstream of APC and GSK3β.
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In VitroKY02111 promotes differentiation by inhibiting WNT signaling in hPSCs.KY02111 induces cardiomyocytes expressed the cardiac markers, αMHC, NKH2.5, and HCN4.KY02111 (1-10 μM; 12 hours, 24 hours) reduces WNT signaling in both IMR90-1 cells and HEK293 cells in a dose-dependent manner.KY02111 treatment with WNT signaling modulators produces robust cardiac differentiation of hPSCs in a xeno-free, defined medium, devoid of serum and any kind of recombinant cytokines and hormones, such as BMP4, Activin A, or insulin.
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In Vivo——
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SynonymsKY02111 | KY 02111 | KY-02111
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PathwayWnt/Notch/Hedgehog
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TargetWnt/beta/catenin
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RecptorWnt
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Research AreaCardiovascular Disease
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Indication——
Chemical Information
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CAS Number1118807-13-8
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Formula Weight376.86
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Molecular FormulaC18H17ClN2O3S
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Purity>98% (HPLC)
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SolubilityDMSO: 75 mg/mL (199.01 mM)
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SMILESO=C(NC1=NC2=CC=C(Cl)C=C2S1)CCC3=CC=C(OC)C(OC)=C3
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Chemical NameN-(6-Chloro-2-benzothiazolyl)-3,4-dimethoxybenzenepropanamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Liu F, et al. J Pharmacol Exp Ther, 2008, 327(3), 827-839.
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