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Salinomycin
CAS No. 53003-10-4
Salinomycin( AHR 3096 | AHR3096 | AHR-3096 | K 364 | Salinomycin | BioCox | Sacox | Salocin | Coxistac )
Catalog No. M14878 CAS No. 53003-10-4
Salinomycin is an inhibitor of Wnt/β-catenin signaling, which acts on the Wnt/Fzd/LRP complex.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 41 | In Stock |
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| 5MG | 67 | In Stock |
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| 10MG | 106 | In Stock |
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| 25MG | 197 | In Stock |
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| 50MG | 350 | In Stock |
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| 100MG | 502 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSalinomycin
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NoteResearch use only, not for human use.
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Brief DescriptionSalinomycin is an inhibitor of Wnt/β-catenin signaling, which acts on the Wnt/Fzd/LRP complex.
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DescriptionSalinomycin is an inhibitor of Wnt/β-catenin signaling, which acts on the Wnt/Fzd/LRP complex. Salinomycin strongly suppresses Wnt1-stimulated reporter activity with an IC50 of 163 nM, and reduces β-catenin levels.
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In Vitro——
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In Vivo——
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SynonymsAHR 3096 | AHR3096 | AHR-3096 | K 364 | Salinomycin | BioCox | Sacox | Salocin | Coxistac
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PathwayWnt/Notch/Hedgehog
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TargetWnt/beta/catenin
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RecptorIC50: 163 nM (Wnt1-stimulated reporter)
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Research AreaInfection
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Indication——
Chemical Information
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CAS Number53003-10-4
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Formula Weight751
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Molecular FormulaC??H??O??
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Purity>98% (HPLC)
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SolubilityDMSO:≥ 36.7mg/mL In vivo: Add solvents to the product individually and in order: 10% DMSO+40% PEG300+5% Tween-80+45% saline (clear) ≥2mg/mL ；10% DMSO+90% corn oil (clear) ≥2mg/mL
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SMILESCC[C@@H](C(O)=O)[C@H]1CC[C@@H]([C@H]([C@H]([C@@H]([C@@H](C([C@@H]([C@H]2O[C@]3([C@@H](C[C@@H]2C)C)O[C@]4([C@@H](C=C3)O)CC[C@](O4)([C@H]5CC[C@](CC)([C@@H](O5)C)O)C)CC)=O)C)O)C)O1)C
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Chemical Name(R)-2-((2R,5S,6R)-6-((2S,3S,4S,6R)-6-((2S,5S,7R,9S,10S,12R,15R)-2-((2R,5R,6S)-5-ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.57.35]pentadec-13-en-9-yl)-3-hydroxy-4-methyl-5-oxooctan-2-yl)-5-methyltetrahydro-2H-pyran-2-yl)butanoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lu D, et al. Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells. Proc natl Acad Sci U S A. 2011 Aug 9;108(32):13253-7.
2. Zhou J, et al. Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactiveoxygen species. Toxicol Lett. 2013 Oct 24;222(2):139-45.
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