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JW 67
CAS No. 442644-28-2
JW 67( JW67 )
Catalog No. M27642 CAS No. 442644-28-2
JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
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| 2MG | 51 | In Stock |
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| 5MG | 85 | In Stock |
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| 10MG | 132 | In Stock |
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| 25MG | 273 | In Stock |
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| 50MG | 431 | In Stock |
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| 100MG | 634 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameJW 67
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NoteResearch use only, not for human use.
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Brief DescriptionJW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1.
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DescriptionJW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1.(In Vitro):JW 67 inhibits the canonical Wnt signaling with an IC50 of 1.17μM. JW 67 (1 μM) increased concentration of AXIN2 and decreased the active form of β-catenin. JW 67 (10 or 25μM) reduced growth of SW480 CRC cells in vitro by inhibiting cell-cycle progression at the G1/S.
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In VitroJW67 (1 μM; 24 hours) increases concentration of AXIN2 and decreases the active form of β-catenin.JW67 affects the expression of Wnt target genes and reduces cell growth of colon cancer cell lines.JW67 shows a concentration dependent reduction in proliferation with a GI50 value of 7.8 μM. Western Blot Analysis Cell Line:SW480 cells Concentration:1 μM Incubation Time:24 hours Result:Increased the AXIN2 expression.RT-PCR Cell Line:SW480 cells Concentration:10 or 25μM Incubation Time:72 hours Result:Reduced growth of SW480 CRC cells in vitro by inhibiting cell-cycle progression at the G1/S.
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In Vivo——
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SynonymsJW67
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PathwayWnt/Notch/Hedgehog
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TargetWnt/beta/catenin
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number442644-28-2
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Formula Weight394.383
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Molecular FormulaC21H18N2O6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (126.78 mM)
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SMILESO=C1Nc2ccccc2C11OCC2(CO1)COC1(OC2)C(=O)Nc2ccccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ong AM, et al. A 51-item calcium-focused food frequency questionnaire is a reliable tool to assess dietary calcium intake in postmenopausal women. Nutr Res. 2017 Jul;43:33-42.
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