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Linopirdine

CAS No. 105431-72-9

Linopirdine( DUP-996 | Linopirine )

Catalog No. M10251 CAS No. 105431-72-9

Linopirdine (DUP-996;Linopirine) is a potent Kv7 (KCNQ) voltage-gated potassium channels blcoker; blocks KV7.1+7.3 (KCNQ2+3)/M-currents (IC50=4-7 uM) and KV7.1 (KCNQ1) homomeric channels (IC50=8.9 uM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 46 Get Quote
5MG 72 Get Quote
10MG 115 Get Quote
25MG 215 Get Quote
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100MG 531 Get Quote
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Biological Information

  • Product Name
    Linopirdine
  • Note
    Research use only, not for human use.
  • Brief Description
    Linopirdine (DUP-996;Linopirine) is a potent Kv7 (KCNQ) voltage-gated potassium channels blcoker; blocks KV7.1+7.3 (KCNQ2+3)/M-currents (IC50=4-7 uM) and KV7.1 (KCNQ1) homomeric channels (IC50=8.9 uM).
  • Description
    Linopirdine (DUP-996;Linopirine) is a potent Kv7 (KCNQ) voltage-gated potassium channels blcoker; blocks KV7.1+7.3 (KCNQ2+3)/M-currents (IC50=4-7 uM) and KV7.1 (KCNQ1) homomeric channels (IC50=8.9 uM); inhibits M-type K+ current, increases acetylcholine release in rat hippocampal CA1 neurons; active in vivo.Alzheimer Disease Phase 1 Discontinued.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male Sprague-Dawley rats (300-350 g)Dosage:0.1, 0.5, 1, 3, 6 mg/kg Administration:5 intravenous bolus injections of increasing dosesResult:Transiently and dose-dependently increases MAP by up to 15%.
  • Synonyms
    DUP-996 | Linopirine
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Potassium Channel
  • Research Area
    Neurological Disease
  • Indication
    Alzheimer Disease

Chemical Information

  • CAS Number
    105431-72-9
  • Formula Weight
    391.465
  • Molecular Formula
    C26H21N3O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (319.32 mM)
  • SMILES
    O=C1N(C2=CC=CC=C2)C3=C(C=CC=C3)C1(CC4=CC=NC=C4)CC5=CC=NC=C5
  • Chemical Name
    1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Schnee ME, et al. J Pharmacol Exp Ther. 1998 Aug;286(2):709-17. 2. Wang HS, et al. Science. 1998 Dec 4;282(5395):1890-3. 3. Zaczek R, et al. J Pharmacol Exp Ther. 1998 May;285(2):724-30.
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