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Home - Products - Cell Cycle/DNA Damage - Potassium Channel - BMS-191011

BMS-191011

CAS No. 202821-81-6

BMS-191011( BMS-A )

Catalog No. M20837 CAS No. 202821-81-6

BMS-191011 is an activator of large-conductance calcium-activated potassium (BKCa) channels effective in stroke models.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 55 In Stock
2MG 32 In Stock
5MG 48 In Stock
10MG 75 In Stock
25MG 155 In Stock
50MG 286 In Stock
100MG 431 In Stock
200MG Get Quote In Stock
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1G Get Quote In Stock
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Biological Information

  • Product Name
    BMS-191011
  • Note
    Research use only, not for human use.
  • Brief Description
    BMS-191011 is an activator of large-conductance calcium-activated potassium (BKCa) channels effective in stroke models.
  • Description
    BMS-191011 is an activator of large-conductance calcium-activated potassium (BKCa) channels effective in stroke models.
  • In Vitro
    BMS-191011 (20 or 40 μM) activates BK channels in IGR39 cells, and leads to potentiation in Panc-1 cells. Cell Viability Assay Cell Line:IGR39 and Panc-1 cells Concentration:20 or 40 μM Incubation Time:Result:Activated BK channels in less than 50% IGR39 cells and led to less than two-fold potentiation in Panc-1 cells.Promoted the activation of a voltage-independent K+ conductance at negative voltages.
  • In Vivo
    BMS-191011 (intravenous injection; 10-100 μg/kg; once) dilates rat retinal arterioles through activation of iberiotoxin-sensitive BK(Ca) channels in vivo. Animal Model:Male Wistar rats (8- to 10-week-old) treated with Tetrodotoxin (50 μg/kg, intravenously (i.v.)) Dosage:10-100 μg/kg Administration:Intravenous injection; 10-100 μg/kg; once Result:Increased the diameter of retinal arterioles, showed no significant effect on mean arterial pressure and heart rate.
  • Synonyms
    BMS-A
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Potassium Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    202821-81-6
  • Formula Weight
    370.71
  • Molecular Formula
    C16H10ClF3N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL (337.19 mM)
  • SMILES
    O=c1oc(-c2ccc(C(F)(F)F)cc2)nn1Cc1cc(Cl)ccc1O
  • Chemical Name
    134-Oxadiazol-2(3H)-one 3-((5-chloro-2-hydroxyphenyl)methyl)-5-(4-(trifluoromethyl)phenyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Mori A Suzuki S Sakamoto K et al. BMS-191011 an Opener of Large-Conductance Ca2+-Activated Potassium Channels Dilates Rat Retinal Arterioles in Vivo[J]. Biological & Pharmaceutical Bulletin 2011 34(1):150-152.
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