NSC 145366( NSC145366 )

Catalog No. M10250 CAS No. 1052515-37-3

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Datasheet

HNMR

HPLC

MSDS

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Product Name

NSC 145366
Note

Research use only, not for human use.
Brief Description

NSC 145366 is a novel, allosteric Hsp90 CTD (C-terminal domain) inhibitor.
Description

NSC 145366 is a novel, allosteric Hsp90 CTD (C-terminal domain) inhibitor, exhibits anti-proliferative activity in tumor cell lines with GI50 of 0.2-1.9 uM; increases Hsp90 oligomerization resulting in allosteric inhibition of NTD ATPase activity (IC50=119 uM), but does not compete with NTD or CTD-ATP binding; causes selective client protein downregulation including AR and BRCA1 but without a heat shock response in LNCaP prostate tumor cells.
In Vitro

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In Vivo

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Synonyms

NSC145366
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

HSP
Recptor

HSP
Research Area

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Indication

——

CAS Number

1052515-37-3
Formula Weight

635.371
Molecular Formula

C37H63ClN2O4
Purity

>98% (HPLC)
Solubility

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SMILES

CC(C1=CC=C(OCC(O)CNC(C)(C)CC(C)(C)C)C=C1)(C2=CC=C(OCC(O)CNC(C)(C)CC(C)(C)C)C=C2)C.[H]Cl.[H]Cl
Chemical Name

1-[4-[2-[4-[2-hydroxy-3-(2,4,4-trimethylpentan-2-ylamino)propoxy]phenyl]propan-2-yl]phenoxy]-3-(2,4,4-trimethylpentan-2-ylamino)propan-2-ol hydrochloride

1. Thomas FM, et al. SLAS Discov. 2017 Jul;22(6):706-719. 2. Goode KM, et al. Biochim Biophys Acta. 2017 Aug;1861(8):1992-2006.

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