ML-162( ML 162 | ML162 )

Catalog No. M10173 CAS No. 1035072-16-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

ML-162
Note

Research use only, not for human use.
Brief Description

A small-molecule probe that selectively kills cells induced to express mutant RAS.
Description

A small-molecule probe that selectively kills cells induced to express mutant RAS; inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM, displays 23-fold sensitivity over BJeH-LT (isogenic to BJeLR without HRAS G12V) cell lines; a useful tool for identifying oncogene-specific pathways and targets in cancer cells.
In Vitro

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In Vivo

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Synonyms

ML 162 | ML162
Pathway

MAPK/ERK Signaling
Target

Ras
Recptor

Ras
Research Area

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Indication

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CAS Number

1035072-16-2
Formula Weight

477.4
Molecular Formula

C23H22CI2N2O3S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (209.47 mM)
SMILES

COC1=C(C=C(C=C1)N(C(C2=CC=CS2)C(=O)NCCC3=CC=CC=C3)C(=O)CCl)Cl
Chemical Name

2-chloro-N-(3-chloro-4-methoxyphenyl)-N-(2-oxo-2-(phenethylamino)-1-(thiophen-2-yl)ethyl)acetamide

1. We?wer M, et al. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6. 2. Bittker JA, et al. Probe Reports from the NIH Molecular Libraries Program.

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