Cart
sales@molnova.com
ML-162
CAS No. 1035072-16-2
ML-162( ML 162 | ML162 )
Catalog No. M10173 CAS No. 1035072-16-2
A small-molecule probe that selectively kills cells induced to express mutant RAS.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 84 | In Stock |
|
| 5MG | 78 | In Stock |
|
| 10MG | 112 | In Stock |
|
| 25MG | 227 | In Stock |
|
| 50MG | 346 | In Stock |
|
| 100MG | 483 | In Stock |
|
| 200MG | 694 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameML-162
-
NoteResearch use only, not for human use.
-
Brief DescriptionA small-molecule probe that selectively kills cells induced to express mutant RAS.
-
DescriptionA small-molecule probe that selectively kills cells induced to express mutant RAS; inhibits BJeLR (expressing HRAS G12V) cell lines with IC50 of 25 nM, displays 23-fold sensitivity over BJeH-LT (isogenic to BJeLR without HRAS G12V) cell lines; a useful tool for identifying oncogene-specific pathways and targets in cancer cells.
-
In Vitro——
-
In Vivo——
-
SynonymsML 162 | ML162
-
PathwayMAPK/ERK Signaling
-
TargetRas
-
RecptorRas
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1035072-16-2
-
Formula Weight477.4
-
Molecular FormulaC23H22CI2N2O3S
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (209.47 mM)
-
SMILESCOC1=C(C=C(C=C1)N(C(C2=CC=CS2)C(=O)NCCC3=CC=CC=C3)C(=O)CCl)Cl
-
Chemical Name2-chloro-N-(3-chloro-4-methoxyphenyl)-N-(2-oxo-2-(phenethylamino)-1-(thiophen-2-yl)ethyl)acetamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. We?wer M, et al. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1822-6.
2. Bittker JA, et al. Probe Reports from the NIH Molecular Libraries Program.
molnova catalog
related products
-
NSC 658497
NSC 658497 is a small molecule inhibitor of Ras GEF, SOS1, binds to SOS1 with Kd of 7 uM but no H-Ras.
-
Oncrasin 1
Oncrasin 1 is a potent inhibitor of anticancer that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations.
-
Rac1 Inhibitor W56
Peptide comprising residues 45-60 of the guanine nucleotide exchange factor (GEF) recognition/activation site of Rac1; selectively inhibits Rac1 interaction with Rac1-specific GEFs TrioN, GEF-H1 and Tiam1.
