KRAS4b-PDEδ stablizer C19( —— )

Catalog No. M16988 CAS No. ——

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

KRAS4b-PDEδ stablizer C19
Note

Research use only, not for human use.
Brief Description

KRAS4b-PDEδ stablizer C19 is a small molecule that binds and stablizes the KRAS4b-PDEδ complex.
Description

KRAS4b-PDEδ stablizer C19 is a small molecule that binds and stablizes the KRAS4b-PDEδ complex, decreases the viability and proliferation of colorectal cancer cells; showed high cytotoxicity in the colorectal cancer cell lines HCT116 and LoVo, with a stronger effect in KRAS-dependent LoVo cells. Importantly, C19 significantly decreased tumor size in a xenograft mouse model and showed lower side effects than 5-FU.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

MAPK/ERK Signaling
Target

Ras
Recptor

Ras
Research Area

——
Indication

——

CAS Number

——
Formula Weight

385.285
Molecular Formula

C18H22Cl2N2O3
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

(2S)-N-(2,5-dichlorophenyl)-2-(((3,4-dimethoxycyclohexa-2,5-dien-1-yl)methyl)amino)propanamide

1. Cruz-Nova P, et al. BMC Cancer. 2018 Nov 1;18(1):1056.

Calculator

molnova catalog