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KRAS4b-PDEδ stablizer C19
CAS No. ——
KRAS4b-PDEδ stablizer C19( —— )
Catalog No. M16988 CAS No. ——
KRAS4b-PDEδ stablizer C19 is a small molecule that binds and stablizes the KRAS4b-PDEδ complex.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameKRAS4b-PDEδ stablizer C19
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NoteResearch use only, not for human use.
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Brief DescriptionKRAS4b-PDEδ stablizer C19 is a small molecule that binds and stablizes the KRAS4b-PDEδ complex.
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DescriptionKRAS4b-PDEδ stablizer C19 is a small molecule that binds and stablizes the KRAS4b-PDEδ complex, decreases the viability and proliferation of colorectal cancer cells; showed high cytotoxicity in the colorectal cancer cell lines HCT116 and LoVo, with a stronger effect in KRAS-dependent LoVo cells. Importantly, C19 significantly decreased tumor size in a xenograft mouse model and showed lower side effects than 5-FU.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMAPK/ERK Signaling
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TargetRas
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RecptorRas
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight385.285
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Molecular FormulaC18H22Cl2N2O3
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(2S)-N-(2,5-dichlorophenyl)-2-(((3,4-dimethoxycyclohexa-2,5-dien-1-yl)methyl)amino)propanamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Cruz-Nova P, et al. BMC Cancer. 2018 Nov 1;18(1):1056.
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