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Lemborexant
CAS No. 1369764-02-2
Lemborexant( E-2006 | E2006 )
Catalog No. M11522 CAS No. 1369764-02-2
An orally active, potent, selective, dual Orexin receptor OX1/2 antagonist with binding Ki of 6/3 nM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 588 | Get Quote |
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| 50MG | 1764 | Get Quote |
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| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameLemborexant
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NoteResearch use only, not for human use.
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Brief DescriptionAn orally active, potent, selective, dual Orexin receptor OX1/2 antagonist with binding Ki of 6/3 nM, respectively.
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DescriptionAn orally active, potent, selective, dual Orexin receptor OX1/2 antagonist with binding Ki of 6/3 nM, respectively; exhibits an overall improvement in properties such as the TDI of CYP3A and aqueous solubility, high OXRs antagonist activity and sufficient brain penetration; demonstrates high efficacy in preclinical sleep experiments.Sleep Disorder Phase 3 Clinical.
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In Vitro——
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In Vivo——
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SynonymsE-2006 | E2006
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PathwayGPCR/G Protein
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TargetOrexin Receptor
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RecptorOrexin Receptor
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Research AreaNeurological Disease
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IndicationSleep Disorder
Chemical Information
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CAS Number1369764-02-2
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Formula Weight410.4166
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Molecular FormulaC22H20F2N4O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 30 mg/mL
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SMILESO=C([C@H]1[C@@](C2=CC=CC(F)=C2)(COC3=CN=C(C)N=C3C)C1)NC4=NC=C(F)C=C4
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Chemical NameCyclopropanecarboxamide, 2-[[(2,4-dimethyl-5-pyrimidinyl)oxy]methyl]-2-(3-fluorophenyl)-N-(5-fluoro-2-pyridinyl)-, (1R,2S)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Yoshida Y, et al. J Med Chem. 2015 Jun 11;58(11):4648-64.
2. Beuckmann CT, et al. J Pharmacol Exp Ther. 2017 Aug;362(2):287-295.
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