LB-60-OF61( —— )

Catalog No. M32993 CAS No. 794461-93-1

LB-60-OF61 is a NAMPT inhibitor that exhibits antiproliferative activity against MYC oncogene-dependent cancer cell lines (brackets).

Purity : >98% (HPLC)

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Biological Information

Product Name

LB-60-OF61
Note

Research use only, not for human use.
Brief Description

LB-60-OF61 is a NAMPT inhibitor that exhibits antiproliferative activity against MYC oncogene-dependent cancer cell lines (brackets).
Description

LB-60-OF61 is a NAMPT inhibitor and is a cytotoxic compound with a selectivity towards MYC overexpressing cell lines.
In Vitro

LB-60-OF61 is potent against HCT116 cells with an IC50 around 30?nM as measured in a 384 well format.
In Vivo

——
Synonyms

——
Pathway

Metabolic Enzyme/Protease
Target

NAMPT
Recptor

NAMPT
Research Area

——
Indication

——

Chemical Information

CAS Number

794461-93-1
Formula Weight

494.59
Molecular Formula

C29H30N6O2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 200 mg/mL (404.38 mM; Ultrasonic )
SMILES

O=C(NCc1cccnc1)c1ccc(OCc2cc3cnc(nc3n2CCC2CCCCC2)C#N)cc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Estoppey D, et al. Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells. Sci Rep. 2017 Feb 16;7:42728.?

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