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Home - Products - Metabolic Enzyme/Protease - Phosphatase - KY-226

KY-226

CAS No. 1621673-53-7

KY-226( —— )

Catalog No. M20927 CAS No. 1621673-53-7

KY-226 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B)(IC50: 0.25 μM)

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    KY-226
  • Note
    Research use only, not for human use.
  • Brief Description
    KY-226 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B)(IC50: 0.25 μM)
  • Description
    KY-226 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B)(IC50: 0.25 μM).
  • In Vitro
    Western Blot Analysis Cell Line:bEnd.3 cells stimulated with LPS Concentration:1 μM Incubation Time:24 hours Result:Rescued lipopolysaccharide-induced reduction of mRNA and protein levels of ZO-1.
  • In Vivo
    Animal Model:Male db/db mice (8-11 weeks old)Dosage:10 mg/kg and 30 mg/kg Administration:Oral administration; daily; for 4 weeks Result:Significantly reduced plasma glucose and triglyceride levels as well as hemoglobin A1c values without increasing body weight gain.
  • Synonyms
    ——
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    Phosphatase
  • Recptor
    PTP1B
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1621673-53-7
  • Formula Weight
    481.67
  • Molecular Formula
    C27H31NO3S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (519.03 mM)
  • SMILES
    CCCCCCS(=O)(=O)NC(=O)c1ccc(CSCc2ccc(-c3ccccc3)cc2)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ito Y Fukui M Kanda M et al. Therapeutic effects of the allosteric protein tyrosine phosphatase 1B inhibitor KY-226 on experimental diabetes and obesity via enhancements in insulin and leptin signaling in mice[J]. Journal of Pharmacological Sciences 2018:S1347861318300422.
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