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m-3M3FBS
CAS No. 200933-14-8
m-3M3FBS( —— )
Catalog No. M22097 CAS No. 200933-14-8
m-3M3FBS is a phospholipase C (PLC) activator. m-3M3FBS stimulated a transient intracellular calcium concentration ([Ca(2+)](i)) increase in neutrophils.?
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product Namem-3M3FBS
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NoteResearch use only, not for human use.
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Brief Descriptionm-3M3FBS is a phospholipase C (PLC) activator. m-3M3FBS stimulated a transient intracellular calcium concentration ([Ca(2+)](i)) increase in neutrophils.?
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Descriptionm-3M3FBS is a phospholipase C (PLC) activator. m-3M3FBS stimulated a transient intracellular calcium concentration ([Ca(2+)](i)) increase in neutrophils.?Moreover, m-3M3FBS stimulated the formation of inositol phosphates in U937 cells, indicating that it stimulates PLC activity.?The compound showed no cell-type specificity in terms of [Ca(2+)](i) increase in the various cell lines including leukocytes, fibroblasts, and neuronal cells,?also ruled out the possible involvement of heterotrimeric G proteins in m-3M3FBS-stimulated signaling by confirming the following: 1) pertussis toxin does not inhibit m-3M3FBS-induced [Ca(2+)](i) increase;?2) m-3M3FBS does not stimulate cyclic AMP generation;?and 3) the inhibition of G(q) by the regulator of G protein-signaling 2 does not affect the m-3M3FBS-induced [Ca(2+)](i) increase.?m-3M3FBS stimulated PLC activity in vitro.?The purified isoforms of PLC that were tested (i.e., beta2, beta3, gamma1, gamma2, and delta1) were activated by m-3M3FBS and showed no isoform specificity.
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In Vitrom-3M3FBS (5-50 μM) stimulates the formation of inositol phosphates in U937 cells.m-3M3FBS (50 μM; 24 hours) inhibits the growth of the leukemic cell lines U937 and THP-1, but not primary monocytes.m-3M3FBS (50 μM; 24 hours) induces U937 cell apoptosis. Cell Viability AssayCell Line:U937 and THP-1 cells Concentration:50 μM Incubation Time:24 hours Result:Inhibited the growth of the leukemic cell lines U937 and THP-1, but not primary monocytes.Cell Viability Assay Cell Line:U937 cells Concentration:50 μM Incubation Time:24 hoursResult:The apoptotic rate of m-3M3FBS-treated cells was 53.9%.
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In Vivo——
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetPhosphatase
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RecptorPLC|Apoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number200933-14-8
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Formula Weight343.36
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Molecular FormulaC16H16F3NO2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (291.24 mM)
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SMILESCc1cc(C)c(c(C)c1)S(=O)(=O)Nc1cccc(c1)C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bae YS, et al. Identification of a compound that directly stimulates phospholipase C activity. Mol Pharmacol. 2003;63(5):1043-1050.2. Lee YN, et al. The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis. Cancer Lett. 2005;222(2):227-235.
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