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KUNB 31

CAS No. 2220263-80-7

KUNB 31( KUNB31 )

Catalog No. M13541 CAS No. 2220263-80-7

KUNB 31 is a potent, isoform-selective Hsp90β inhibitor with Kd of 0.18 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    KUNB 31
  • Note
    Research use only, not for human use.
  • Brief Description
    KUNB 31 is a potent, isoform-selective Hsp90β inhibitor with Kd of 0.18 uM.
  • Description
    KUNB 31 is a potent, isoform-selective Hsp90β inhibitor with Kd of 0.18 uM, displays 50-fold selectivity over Hsp90α and Grp94; exhibits anti-proliferative activity against NCI H23, UC3, and HT-29 cancer cell lines with IC50 of 6.74?μM, 3.01?μM, and 3.72 μM, respectively; specificly induces the degradation of Hsp90β-dependent client proteins (EGFR, HER2, CDK4, CDK6, CXCR4 etc.) in cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    KUNB31
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    HSP
  • Recptor
    HSP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2220263-80-7
  • Formula Weight
    322.364
  • Molecular Formula
    C19H18N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(C1=CC(C(C)C)=C(ON=C2)C2=C1O)N3CC4=C(C=CC=C4)C3
  • Chemical Name
    (4-hydroxy-7-isopropylbenzo[d]isoxazol-5-yl)(isoindolin-2-yl)methanone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Khandelwal A, et al. Nat Commun. 2018 Jan 30;9(1):425.
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