PU-H71 HCl

CAS No. 2095432-24-7

PU-H71 HCl( —— )

Catalog No. M36291 CAS No. 2095432-24-7

PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 409 In Stock
10MG 604 In Stock
25MG 938 In Stock
50MG 1265 In Stock
100MG 1702 In Stock
200MG Get Quote In Stock
500MG 3422 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    PU-H71 HCl
  • Note
    Research use only, not for human use.
  • Brief Description
    PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT.
  • Description
    PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT. PU-H71 HCL shows antitumor activity in many preclinical models of malignancy. PU-H71 HCL has an inhibitory effect on the protein expression levels of Rad51 and Ku70, which may be associated with the double chain break repair in the homologous recombination pathway and non-homologous end-joining pathway.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    HSP
  • Recptor
    HSP | DNA/RNA Synthesis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2095432-24-7
  • Formula Weight
    548.83
  • Molecular Formula
    C18H22ClIN6O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cl.IC=1C=C2OCOC2=CC1SC3=NC=4C(=NC=NC4N3CCCNC(C)C)N
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

molnova catalog
related products
  • 4-Br-BnIm

    A potent, subtype-selective Grp94 inhibitor with Kd of 0.96 uM.

  • MAL3-101

    MAL3-101 is a Hsc70 modulator that inhibits Hsp70 ATPase activity, exhibits antiproliferative activity in breast cancer cells SK-BR-3 with IC50 of 27 uM.

  • YZ129

    YZ129 (YZ-129) is a small molecule inhibitor of HSP90-Calcineurin-NFAT pathway, suppresses TG-induced NFAT nuclear translocation in HeLa cellswith IC50 of 820 nM.