JNJ-42905343( JNJ 42905343 | JNJ42905343 )

Catalog No. M10958 CAS No. 1238689-36-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

JNJ-42905343
Note

Research use only, not for human use.
Brief Description

JNJ-42905343 is a potent, selective, orally active prolyl hydroxylase (PHD) inhibitor.
Description

JNJ-42905343 is a potent, selective, orally active prolyl hydroxylase (PHD) inhibitor with pKi of 8.07, 7.48 and 7.27 for PHD1, PHD2 and PHD3 respectively; stabilizes HIF1-α in a concentration-dependent fashion in HeLa cells (EC50=19.7 uM) and stimulates the release of EPO from Hep3B cells (EC50=20.3 uM); increases blood haemoglobin, mean corpuscular haemoglobin (MCH) and mean corpuscular volume (MCV), corrects functional iron deficiency and inflammation-induced anaemia in rats.
In Vitro

——
In Vivo

——
Synonyms

JNJ 42905343 | JNJ42905343
Pathway

Angiogenesis
Target

HIF/HIF Prolyl-hydroxylase
Recptor

HIF/HIF Prolyl-hydroxylase
Research Area

——
Indication

——

CAS Number

1238689-36-5
Formula Weight

394.362
Molecular Formula

C20H15FN4O4
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

1-(6-(2,6-dimethylphenoxy)-7-fluoro-4-oxo-3,4-dihydroquinazolin-2-yl)-1H-pyrazole-4-carboxylic acid

1. Barrett TD, et al. Br J Pharmacol. 2015 Aug;172(16):4078-88.

Calculator

molnova catalog