Dimethyloxaloylglycine

Research use only, not for human use.

DMOG is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolyl hydroxylase.

DMOG is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolyl hydroxylase.(In Vitro):DMOG efficiently suppresses hydroxyproline synthesis in intact cells, but shows only weakly active in the microsomal system. DMOG reduces FGF-2-induced proliferation and cyclin A expression by inhibiting prolyl hydroxylase activity in HPASMC.(In Vivo):DMOG inhibits endogenous HIF inactivation, and induces angiogenesis in ischaemic skeletal muscles of mice. Up-regulation of hypoxia-inducible factor-1α by DMOG enhances the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats.

DMOG efficiently suppresses hydroxyproline synthesis in intact cells, but shows only weakly active in the microsomal system.?DMOG reduces FGF-2-induced proliferation and cyclin A expression by inhibiting prolyl hydroxylase activity in HPASMC.

DMOG inhibits endogenous HIF inactivation, and induces angiogenesis in ischaemic skeletal muscles of mice. Up-regulation of hypoxia-inducible factor-1α by DMOG enhances the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats.

DMOG

Angiogenesis

HIF/HIF Prolyl-hydroxylase

HIF-PH

Cancer

——

89464-63-1

175.14

C6H9NO5

>98% (HPLC)

Soluble in DMSO

O=C(OC)CNC(C(OC)=O)=O

N-(methoxyoxoacetyl)-glycine, methyl ester

(-20℃)

With Ice Pack

≥ 2 years