Cart
sales@molnova.com
Dimethyloxaloylglycine
CAS No. 89464-63-1
Dimethyloxaloylglycine ( DMOG )
Catalog No. M16443 CAS No. 89464-63-1
DMOG is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolyl hydroxylase.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 48 | In Stock |
|
| 10MG | 30 | In Stock |
|
| 25MG | 45 | In Stock |
|
| 50MG | 54 | In Stock |
|
| 100MG | 84 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 249 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameDimethyloxaloylglycine
-
NoteResearch use only, not for human use.
-
Brief DescriptionDMOG is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolyl hydroxylase.
-
DescriptionDMOG is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolyl hydroxylase.(In Vitro):DMOG efficiently suppresses hydroxyproline synthesis in intact cells, but shows only weakly active in the microsomal system. DMOG reduces FGF-2-induced proliferation and cyclin A expression by inhibiting prolyl hydroxylase activity in HPASMC.(In Vivo):DMOG inhibits endogenous HIF inactivation, and induces angiogenesis in ischaemic skeletal muscles of mice. Up-regulation of hypoxia-inducible factor-1α by DMOG enhances the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats.
-
In VitroDMOG efficiently suppresses hydroxyproline synthesis in intact cells, but shows only weakly active in the microsomal system.?DMOG reduces FGF-2-induced proliferation and cyclin A expression by inhibiting prolyl hydroxylase activity in HPASMC.
-
In VivoDMOG inhibits endogenous HIF inactivation, and induces angiogenesis in ischaemic skeletal muscles of mice. Up-regulation of hypoxia-inducible factor-1α by DMOG enhances the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats.
-
SynonymsDMOG
-
PathwayAngiogenesis
-
TargetHIF/HIF Prolyl-hydroxylase
-
RecptorHIF-PH
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number89464-63-1
-
Formula Weight175.14
-
Molecular FormulaC6H9NO5
-
Purity>98% (HPLC)
-
SolubilitySoluble in DMSO
-
SMILESO=C(OC)CNC(C(OC)=O)=O
-
Chemical NameN-(methoxyoxoacetyl)-glycine, methyl ester
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Baader E, et al. Biochem J. 1994, 300 ( Pt 2), 525-530.
molnova catalog
related products
-
24-DPD
24-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH).
-
103D5R
103D5R is a small-molecule inhibitor of HIF-1α that displays an EC50 of 35 uM against hypoxia-induced alkaline phosphatase enzymatic reporter activity.
-
TAT-cyclo-CLLFVY
Selective HIF-1 dimerization inhibitor. Blocks protein-protein interaction of recombinant HIF-1α, but not HIF-2α, with HIF-1β (IC50 = 1.3 μM). Inhibits hypoxia-induced HIF-1 activity, and decreases VEGF and CAIX expression in osteosarcoma and breast cancer cells in vitro. Also reduces tubularization of hypoxic HUVECs.
