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HyT36

CAS No. 1323151-45-6

HyT36( —— )

Catalog No. M36434 CAS No. 1323151-45-6

HyT36 is a small molecule hydrophobic tag that selectively destabilizes and promotes the degradation of fusion proteins and the pseudokinase Her3.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    HyT36
  • Note
    Research use only, not for human use.
  • Brief Description
    HyT36 is a small molecule hydrophobic tag that selectively destabilizes and promotes the degradation of fusion proteins and the pseudokinase Her3.
  • Description
    HyT36 is a low molecular weight hydrophobic tag that promotes the degradation of fusion protein and pseudokinase Her3.
  • In Vitro
    Western Blot Analysis Cell Line:HEK293 cells expressing GFP-HaloTag2/Fz4-HaloTag2/HA-EGFP-HaloTag2 or NIH-3T3 cells expressing HA?HaloTag2?HRasG12V.Concentration:1 μM or 10 μM.Incubation Time: 2 h, 24 h or 4 days.Result:Decreased the expression of fusion proteins and increased the binding of Hsp70 and HA-EGFP-HaloTag2 fusion protein.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    HER/HSP
  • Recptor
    HER
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1323151-45-6
  • Formula Weight
    442.07
  • Molecular Formula
    C25H44ClNO3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (226.21 mM; Ultrasonic )
  • SMILES
    C(C[C@H](C(NCCOCCOCCCCCCCl)=O)C)C12CC3CC(C1)CC(C2)C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tae HS, et al. Identification of hydrophobic tags for the degradation of stabilized proteins. Chembiochem. 2012 Mar 5;13(4):538-41.?
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