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MCHR1 antagonist 2

CAS No. 863115-70-2

MCHR1 antagonist 2( —— )

Catalog No. M26291 CAS No. 863115-70-2

MCHR1 antagonist 2 is an antagonist of melanin-concentratin hormone receptor 1(MCH1-R, IC50 = 65 nM) and also inhibits hERG.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MCHR1 antagonist 2
  • Note
    Research use only, not for human use.
  • Brief Description
    MCHR1 antagonist 2 is an antagonist of melanin-concentratin hormone receptor 1(MCH1-R, IC50 = 65 nM) and also inhibits hERG.
  • Description
    MCHR1 antagonist 2 is an antagonist of melanin-concentratin hormone receptor 1(MCH1-R, IC50 = 65 nM) and also inhibits hERG.(In Vitro):In IMR-32 cells, MCHR1 antagonist 2 shows inhibitory effects on Ca2+ flux, and hERG, with IC50s of 196 ± 30 nM and 4.0 ± 0.8 nM, respectively.
  • In Vitro
    MCHR1 antagonist 2 (Compound 30) is an antagonist of melanin concentrating hormone receptor 1, with an IC50 of 65 nM. MCHR1 antagonist 2 has inhibitory effects on Ca2+?flux, and hERG, with IC50s of 196?±?30 nM and 4.0?±?0.8 nM, respectively, in IMR-32 cells.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    HER/HSP
  • Recptor
    APC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    863115-70-2
  • Formula Weight
    424.428
  • Molecular Formula
    C23H21FN2O5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 10 mg/mL (23.56 mMul)
  • SMILES
    Fc1ccc2oc(cc(=O)c2c1)C(=O)NC1CCN(Cc2ccc3OCOc3c2)CC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Bai R L, Pettit G R, Hamel E. Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites. Journal of Biological Chemistry, 1990, 265(28): 17141-17149.
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