HTS07545( —— )

Catalog No. M35541 CAS No. 118666-03-8

HTS07545 is a potent sulfide:quinone oxidoreductase inhibitor (IC50: 30 nM) that reduces the rate of hydrogen sulfide (H2S) decomposition and has been used in heart failure studies.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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10MG	140	Get Quote
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Biological Information

Product Name

HTS07545
Note

Research use only, not for human use.
Brief Description

HTS07545 is a potent sulfide:quinone oxidoreductase inhibitor (IC50: 30 nM) that reduces the rate of hydrogen sulfide (H2S) decomposition and has been used in heart failure studies.
Description

HTS07545 is a potent sulfide:quinone oxidoreductase (SQOR) inhibitor with an IC50 of 30 nM. HTS07545 decrease the rate of breakdown of hydrogen sulfide (H2S). HTS07545 can be used for heart failure research.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Membrane Transporter/Ion Channel
Target

NADPH
Recptor

NADPH
Research Area

——
Indication

——

Chemical Information

CAS Number

118666-03-8
Formula Weight

358.39
Molecular Formula

C22H18N2O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (279.03 mM; Ultrasonic )
SMILES

C(#N)C=1C(=CC(=NC1OCC(OCC)=O)C2=CC=CC=C2)C3=CC=CC=C3
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Simon D P Baugh, et al. Synthesis and evaluation of potent novel inhibitors of human sulfide:quinone oxidoreductase. Bioorg Med Chem Lett. 2021 Dec 15;54:128443. ?

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